Development and Validation of an Noninvasive Model for Predicting High Risk Esophageal Varices in Cirrhosis
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Esophageal and Gastric Varices
- Sponsor
- Qilu Hospital of Shandong University
- Enrollment
- 245
- Locations
- 1
- Primary Endpoint
- specificity
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The aim of the study is to develop and validate a new noninvasive method based on routine examination during clinical practice for predicting high risk esophageal varices in cirrhosis.
Detailed Description
Portal hypertension is the main consequence of cirrhosis. Variceal bleeding is the principal and life-threatening complication of portal hypertension. Endoscopic screening is the golden standard to detect esophageal varices. However, endoscopy is limited by its invasiveness, cost and the discomfort it imposes on patients. With the goal of circumventing these disadvantages, we intend to develop an noninvasive method for predicting high risk esophageal varices.
Investigators
Yanjing Gao
Clinical Professor
Qilu Hospital of Shandong University
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
specificity
Time Frame: through study completion, up to 2 years
the specificity of predicting high risk esophageal varices of the noninvasive model.
Accuracy
Time Frame: through study completion, up to 2 years
The golden standard is endoscopic examination.Compare the accuracy of the noninvasive model with the endoscopic examination.
sensitivity
Time Frame: through study completion, up to 2 years
the sensitivity of predicting high risk esophageal varices of the noninvasive model.