Development and Validation of an Noninvasive Model for Predicting High Risk Esophageal Varices in Cirrhosis
- Conditions
- Esophageal and Gastric Varices
- Registration Number
- NCT04210297
- Lead Sponsor
- Qilu Hospital of Shandong University
- Brief Summary
The aim of the study is to develop and validate a new noninvasive method based on routine examination during clinical practice for predicting high risk esophageal varices in cirrhosis.
- Detailed Description
Portal hypertension is the main consequence of cirrhosis. Variceal bleeding is the principal and life-threatening complication of portal hypertension. Endoscopic screening is the golden standard to detect esophageal varices. However, endoscopy is limited by its invasiveness, cost and the discomfort it imposes on patients. With the goal of circumventing these disadvantages, we intend to develop an noninvasive method for predicting high risk esophageal varices.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 245
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method specificity through study completion, up to 2 years the specificity of predicting high risk esophageal varices of the noninvasive model.
Accuracy through study completion, up to 2 years The golden standard is endoscopic examination.Compare the accuracy of the noninvasive model with the endoscopic examination.
sensitivity through study completion, up to 2 years the sensitivity of predicting high risk esophageal varices of the noninvasive model.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Gastroenterology,Qilu Hospital,Shandong University
🇨🇳Jinan, Shandong, China