Comparative evaluation of Calcium Hydroxide, Triple Antibiotic Paste and Bioceramic as intracanal medicament on endodontic interappointment pain in patients with symptomatic apical periodontitis – A Randomised Control Trial
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- To evaluate Calcium hydroxide Triple Antibiotic Paste and Bioceramic as intracanal medicaments on endodontic interappointment pain in patients with symptomatic apical periodontitis
研究概览
简要总结
This randomized controlled clinical study aims to assess the comparative effectiveness of three intracanal medicaments—Calcium Hydroxide, Triple Antibiotic Paste (TAP), and Bioceramic compounds—on reducing interappointment pain in patients with symptomatic apical periodontitis. Endodontic treatment, while effective for tooth preservation, often presents challenges like pain between appointments, influenced by factors such as necrotic pulp and bacterial infections.
Calcium Hydroxide is known for its antimicrobial effects, while TAP offers broad-spectrum antibacterial action but may cause dentin weakening and tooth discoloration. Bioceramics, being a recent advancement, show promise due to their superior biocompatibility and ability to stimulate healing.
In this in vivo study, 80 patients aged between 18 to 50 years were selected based on strict inclusion and exclusion criteria. They were randomly divided into four groups, each receiving a different medicament, with one serving as a control. Pain levels were assessed using the Wong-Baker FACES Pain Rating Scale at several intervals post-treatment (6, 24, 48, and 72 hours). The outcomes were analyzed statistically to determine which medicament offers superior pain relief.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •Age of the patient 18 to 50 years will be included in the study
- •Both males and females
- •Systemically healthy patients (Category: ASA Class 1)
- •Single rooted tooth diagnosed with symptomatic apical periodontitis.
- •Teeth with necrotic pulp that gave a negative response to vitality testing.
排除标准
- •Non-restorable teeth
- •Presence of endo-perio lesion
- •Teeth associated with acute or chronic apical abscess
- •Teeth with chronic periodontitis
- •Teeth with open apex
- •Teeth with calcified canals
- •Teeth with severe dilaceration
- •Teeth with internal/external root resorption
- •Patient who were allergic to medication that were used in study
- •Patient who were taking medicine that could influence pain perception
- •Patient that had serious medical illness
- •Patient with systemic disorder
- •Patient with immunocompromised disease such as AIDS or HBV.
结局指标
主要结局
To evaluate Calcium hydroxide Triple Antibiotic Paste and Bioceramic as intracanal medicaments on endodontic interappointment pain in patients with symptomatic apical periodontitis
时间窗: 6hrs 48hrs 72 hrs
次要结局
- 2. To compare Calcium hydroxide, Triple Antibiotic Paste and Bioceramic as intracanal medicaments on endodontic interappointment pain in patients with symptomatic apical periodontitis.(3. To analyse Calcium hydroxide, Triple Antibiotic Paste and Bioceramic as intracanal medicaments on endodontic interappointment pain in patients with symptomatic apical periodontitis.)
研究者
Prathamesh Sawant
Ranjeet Deshmukh Dental College and research Center Nagpur