Intravenous Calcium for Facilitating Recovery in Children Hospitalized with Pneumonia and Asymptomatic Hypocalcemia: A Randomized Controlled Study
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Clinical resolution of pneumonia
研究概览
简要总结
Aim of the study is to evaluate the efficacy and safety of intravenous calcium supplementation for enhancing recovery in children hospitalized with pneumonia and asymptomatic hypocalcemia where serum calcium is less than 8.5 mg/dL. Rationale of the study is that calcium plays an essential role in the contraction of respiratory muscles, low serum calcium levels can contribute to respiratory weakness and potentially exacerbate hypoxemia and respiratory failure. Rapid correction of hypocalcemia may help improve respiratory mechanics and enhance recovery in pneumonia. It is hypothesized that giving intravenous calcium to children with pneumonia and asymptomatic hypocalcemia will show faster recovery from illness.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 2.00 Month(s) 至 5.00 Year(s)（—）
- 性别
- All
入选标准
- •Children diagnosed with pneumonia/severe pneumonia based on WHO classification, requiring hospitalization and detected to be having asymptomatic hypocalcemia.
排除标准
- •1.Children with known chronic comorbidities (e.g., congenital heart disease, immunodeficiency, neurological disorders).
- •2.Severe acute malnutrition 3.Children with complicated pneumonia (Empyema, lung abscess, massive pleural effusion) 4.Children presenting with shock, convulsions, requiring resuscitation or mechanical ventilation before enrolment.
- •5.Children who received oral/parenteral calcium within last 7 days before enrolment.
结局指标
主要结局
Clinical resolution of pneumonia
时间窗: Time for clinical resolution of pneumonia (in hours) from the time of enrolment
次要结局
- 1.Resolution of chest retractions, or tachypnea(2.Oxygen requirement)
研究者
Vivek Vats
University college of medical sciences and GTB Hospital