Clinical and molecular genetic aspects of idiopathic epilepsies - genetics of idiopathic epilepsies

Epilepsiecentrum Kempenhaeghe0 个研究点目标入组 300 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•1. Patients with a familial history of epilepsy, with multiple (at least 4) family members affected
•2. Patients with a severe form of epilepsy with onset in the first year of life in which no acquired cause can be detected.
•3. patients with a combination of epilepsy, mental retardation and dysmorphia (=contiguous gene syndrome, probably caused by deletion/duplication of multiple genes and detectable by CGH)
•4. Patients on a ketogenic diet with epilepsy of unknown origin
•Theoretically there are no age restrictions. In case of severe epilepsy with early onset (cfr.2), cases with neonatal onset will also be included, but as DNA diagnostics in a genetic research setting only will be done after all other possible causes are excluded, inclusion in this study in actual practice will only be done after 2 months of life.

•Patients in which a acquired cause of epilepsy is suspected (for example perinatal brain damage, lesions visible on MRI,...)

发起方

Epilepsiecentrum Kempenhaeghe