Establishing Cognitive and Neural Assessment Platform and Localized Norm for Macau Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Normative Data for the Montreal Cognitive Assessment - Chinese (Hong Kong) version
研究概览
简要总结
The current project is dedicated to creating a comprehensive cognitive and neural assessment platform and corresponding norms tailored specifically to the older adults in Macau.
详细描述
The investigators will establish this assessment platform using a combination of methods, including interviews, surveys, and expert reviews.
Steps include adapting existing assessment methods to the Macau context, developing new cognitive and neural tasks, defining standardized procedures, seeking external expert input, conducting pilot tests, and validation processes, and refining both the platform and its accompanying manual.
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Must be a local adult resident of Macau
- •Age above 50 years for older adult cohort
- •Younger adults individuals above 18 will be included as control comparators
排除标准
- •History of neurological injury or disease
- •Current use of medications that affect brain function or blood flow
- •Contraindications to MRI scanning, such as the presence of an electric/mechanical implant or device (e.g., pacemaker)
- •Claustrophobia
- •Body weight over 300 lbs due to weight and physical constraints of the scanner (i.e., bore size limited to 55 cm)
- •Inability to provide informed consent
- •Pregnancy
- •Being under the legal age of adulthood (children)
- •Incarcerated individuals (prisoners)
结局指标
主要结局
Normative Data for the Montreal Cognitive Assessment - Chinese (Hong Kong) version
时间窗: From February 2024 to January 2026
The MoCA will be administered to derive a normative data set representative of the older adult population in Macau.
Normative Scores for Computerized Neuropsychological Tasks
时间窗: From February 2024 to January 2026
Neuropsychological tasks will be employed to measure selective attention capacity and processing speed in the study cohort. These tasks will provide quantifiable data on the efficiency and accuracy of cognitive processing. The collective performance on these tasks will be used to establish benchmark values - including means, medians, and ranges - that define the normative standards for these cognitive abilities in the population.
Normative Data for the Mini-Mental State Examination (MMSE)
时间窗: From February 2024 to January 2026
The MMSE will be administered to derive a normative data set representative of the older adult population in Macau.
次要结局
- Neural Activation Patterns During Cognitive Tasks as Revealed by Functional Magnetic Resonance Imaging (fMRI)(From February 2024 to January 2026)
- Electrophysiological Correlates of Cognitive Activity as Measured by Electroencephalography (EEG)(From February 2024 to January 2026)
- Cerebral Hemodynamics Assessed Through Functional Near-Infrared Spectroscopy (fNIRS)(From February 2024 to January 2026)