跳至主要内容
临床试验/NCT07116382
NCT07116382已完成不适用

Risk Factors of Ventilator-Associated Pneumonia in Critically Ill Population of Alexandria; Case-Control Study

Suez Canal University1 个研究点 分布在 1 个国家目标入组 180 人开始时间: 2025年2月20日最近更新:

试验速览

阶段
不适用
状态
已完成
入组人数
180
试验地点
1
主要终点
In-ICU mortality

研究概览

简要总结

The aim of the study is to compare cases of ventilator-associated pneumonia with matched controls of mechanically ventilated patients to identify any relevant independent risk factors for ventilator-associated pneumonia. All adult (≥ 18 years) mechanically ventilated patients > 48 hours who are diagnosed with ventilator-associated pneumonia are considered as cases. The control group are mechanically ventilated patients and matching with cases regarding their age, gender, and duration of mechanical ventilation.

详细描述

Ventilator-associated pneumonia is associated with long hospital stays and significant costs. It also prolongs the length of mechanical ventilation. Incidences of ventilator associated pneumonia are highly influenced by the characteristics of the patient population studied and the criteria and techniques applied for diagnosis. The reported incidence is ranged between 10-20% of mechanically ventilated patients. This incidence in developed countries differs significantly from that in developing ones due to many reasons. Several risk factors are identified. The risk factors can be host, device, or personnel related. The most reproducible risk factor is the duration of mechanical ventilation.

The most well recognized modifiable risk factors are mainly intervention related causes. Despite widespread ventilator-associated pneumonia prevention efforts, there was a 35% increase in the ventilator associated events between 2019 and 2020. Since critically ill patients are dynamic patients who are in need to multiple interventions and techniques, revisiting the risk factors of VAP is essential.

Despite widespread prevention efforts, VAP prevention bundles, surveillance systems and updating definitions by CDC, there was a 35% increase in the ventilator associated events between 2019 and 2020 according to CDC healthcare associated infections progress report in 2020. Since critically ill patients are dynamic patients who are in need to multiple interventions and techniques, revisiting the modifiable risk factors of VAP is essential.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • All adult (≥ 18 years) mechanically ventilated patients > 48 hours who are diagnosed with VAP (Case Group).
  • The control group is mechanically ventilated (≥ 48 hours) patients and matched with cases regarding their gender, age, and duration of MV.

排除标准

  • Patients with pneumonia prior to MV and those developing pneumonia within 48 hours are excluded from the study.

结局指标

主要结局

In-ICU mortality

时间窗: Up to ICU discharge for a maximum of 3 months

All-Cause Mortality Rate

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

islam elsayed

Researcher, Public Health and Community Medicine Department

Suez Canal University

研究点 (1)

Loading locations...

相似试验

Risk Factors of Ventilator-Associated Pneumonia in... | 临床试验