Hypertension, Dietary Salt and Inflammation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 85
- 试验地点
- 2
- 主要终点
- Pro-inflammatory cytokines
研究概览
简要总结
High dietary salt is associated with immune activation, elevated levels of inflammatory cytokines and hypertension in murine models. Hypertension is independently associated with inflammation in both murine studies and studies in humans. In people living with HIV, these interactions are not well established. The aim of this study is to determine the effect of excess dietary salt on immune cell activation, pro- and anti-inflammatory cytokines and blood pressure between individuals with and without hypertension among people living with HIV and HIV negative persons.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults (aged 18 and above) who will be required to verbally consent and sign a consent form
- •HIV positive or HIV Normotensive individuals or hypertensive If HIV, on antiretroviral therapy ART treated hypertensive individuals
排除标准
- •Existence of comorbidities such as diabetes mellitus and cancer Existing and recent past opportunistic infections, syphilis, hepatitis C and B virus infection and tuberculosis infection;
- •Sick persons (clients seeking healthcare due to an illness rather than routine ART clinic reviews)
- •Those with recent and current alcohol consumption and smoking status
结局指标
主要结局
Pro-inflammatory cytokines
时间窗: 2 weeks: At the end of the low- and high-salt phases
Elevated levels of pro-inflammatory cytokines when compared between low and high salt phase
次要结局
- Blood pressure(2 weeks: At the end of the low- and high-salt phases)
研究者
Sepiso K. Masenga
Dr
Mulungushi University