Multimodal Deep Learning for Predicting Treatment Response to Neoadjuvant Chemoimmunotherapy in Esophageal Cancer
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- pCR
研究概览
简要总结
This observational study aims to investigate a clinical cohort of patients with locally advanced esophageal cancer undergoing neoadjuvant chemoimmunotherapy. By integrating multimodal clinical data-including demographic characteristics, medical history, imaging studies, pathological findings, and laboratory tests-and employing deep learning algorithms, the study seeks to develop predictive models for the early and accurate assessment of treatment response prior to surgery. Specifically, this study focuses on addressing the following key scientific questions:
- Can multimodal clinical data be used to construct an accurate model for predicting pathological complete response (pCR) following neoadjuvant therapy?
- Can deep learning models enable early identification of patients with suboptimal response to neoadjuvant therapy, defined as stable disease (SD) or progressive disease (PD), before surgery?
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with histologically confirmed esophageal cancer based on biopsy results;
- •Patients recommended for neoadjuvant chemoimmunotherapy following multidisciplinary team (MDT) discussion or evaluation by thoracic surgery specialists;
- •Patients who received neoadjuvant chemoimmunotherapy;
- •Patients with complete imaging data before and after neoadjuvant treatment.
排除标准
- •Patients deemed eligible for surgery by the thoracic surgery team but who refused surgical treatment;
- •Patients with missing or poor-quality CT images;
- •Patients with concurrent malignancies other than esophageal cancer;
- •Patients with incomplete clinical data.
研究组 & 干预措施
group 2: Non-pCR
group 2: Non-Pathological Complete Response
group 1: pCR
group 1: Pathologic Complete Response
group 3: Non-Favorable Responses
group 3: SD/PD
group 4: Favorable Response
group 4: Non-SD/PD
结局指标
主要结局
pCR
时间窗: From enrollment to the end of surgery
Pathologic Complete Response
pCR
时间窗: From enrollment to the end of surgery
Pathologic Complete Response
次要结局
- Non-Favorable Responses(From enrollment to the end of surgery)
- Non-Favorable Responses(From enrollment to the end of surgery)
研究者
Chen Chen
Associate Professor
Central South University