Impact of Hemodialysis on Plasma Carnitine Levels in Patients With End Stage Renal Disease
- Conditions
- Hemodialysis Complication
- Interventions
- Registration Number
- NCT05817799
- Lead Sponsor
- Bahria University
- Brief Summary
OBJECTIVES
* To assess the levels of plasma carnitine in controls and hemodialysis patients.
* To give supplementary L-carnitine to study subjects for a duration of 5months.
* To compare the values of plasma carnitine before and after L carnitine supplementation.
* To assess the role of carnitine supplementation on biochemical and clinical parameters.
- Detailed Description
.ABSTRACT INTRODUCTION Dialysis therapy can cause a decrease in both free carnitine and plasma acyl carnitines after only six months of dialysis treatment. A positive correlation between AC/FC ratio and months on HD therapy has been reported. We investigate in this study the role of oral L-carnitine supplementation on anemia, blood pressure, cardiac dysfunction and muscle cramps in hemodialysis patients.
OBJECTIVES
* To assess the levels of plasma carnitine in controls and hemodialysis patients.
* To give supplementary L-carnitine to study subjects for a duration of 5months.
* To compare the values of plasma carnitine before and after L carnitine supplementation.
* To assess the role of carnitine supplementation on biochemical and clinical parameters.
STUDY DESIGN AND SETTING: It will be a case-control study, which will be conducted in the Department of Biochemistry, University of Karachi in collaboration with Nephrology ward of JPMC, Karachi in a period of one year after approval of synopsis.
METHOD: Total 120 subjects will be included in this study which will be divided into two groups. Group A will comprise of 60 subjects of Chronic renal failure who will be the control group. Group B will comprise of 60 subjects who will be on hemodialysis for more than 1 year. Blood samples will be taken after informed consent. Group B subjects will be given L-Carnitine supplementation for five months under strict monitoring. Physical, biochemical and clinical parameters of group B subjects will be compared before and after supplementation.
RESULTS: Data will be analyzed using SPSS version 21. Results will be shared after completion of research.
CONCLUSION: conclusion will be shared after completion of research.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 83
• Individuals of either sex (male and female).
- The study included people between the ages of 18 and 50 who had had dialysis for more than two years without taking additional antioxidants.
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• Individuals with any other chronic ailment, such as cancer or tuberculosis.
- Patients with acute renal failure who are receiving hemodialysis.
- All subjects who refused to take part in the investigation.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description intervention L-Carnitine 500Mg thrice daily L-Carnitine 500mg thrice daily 1g L-Carnitine IV three times a week intervention 1g L-Carnitine IV three times a week L-Carnitine 500mg thrice daily 1g L-Carnitine IV three times a week
- Primary Outcome Measures
Name Time Method L-Carnitine levels in hemodialysis 5 months plasma carnitine will be detected before and after giving intervention (unit μmol/L)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Jinnah Post Graduate Medical Center
🇵🇰Karachi, Sindh, Pakistan