Association Between Confocal Laser Endomicroscopic (CLE) Features and Colorectal Mucosal Microbiome
Completed
- Conditions
- Colorectal NeoplasiaMucosal MicrobiomeHyperplasiaColorectal Inflammation
- Interventions
- Other: the mucosal microbiome in the biopsy specimen was analysed
- Registration Number
- NCT02063919
- Lead Sponsor
- Shandong University
- Brief Summary
The purpose of this study is to determine whether an association between endomicroscopic pattern and colorectal mucosal microbiome exists.
- Detailed Description
The gut microbiome plays a pivotal role in the intestinal pathophysiology. The mucosal microbiome is in the front face of microbiome-host cross-talk. Confocal laser endomicroscopy (CLE) can provide realtime mucosal images during ongoing endoscopy. We hypothesized that the mucosal pattern, here evaluated by endomicroscopy, may constitute specific microbiome niches and participate the evolvement of the mucosal microbiome.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
- 18 years old ≤ age < 80 years old
- Scheduled for colonoscopy in Qilu Hospital
Exclusion Criteria
- antibiotic usage within 2 months
- probiotic or prebiotic usage within 2 months
- ascites
- jaundice
- liver cirrhosis
- impaired renal function
- coagulopathy
- fever
- pregnancy
- breastfeeding
- inability to provide informed consent
- known allergy to fluorescein sodium
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description endomicroscopy the mucosal microbiome in the biopsy specimen was analysed -
- Primary Outcome Measures
Name Time Method The operational taxonomy unit in the colorectal mucosal microbiome. 6 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Gastroenterology, Qilu Hospital, Shandong University
🇨🇳Jinan, Shandong, China