Does Inhaled Busedonide or Fluticasone Impair Adrenal Function?

Terminated

• Conditions: Adrenal Insufficiency

• Registration Number: NCT00560625
• Lead Sponsor: HaEmek Medical Center, Israel

Brief Summary

Inhaled corticosteroids are largely used in patients with asthma or chronic obstructive lung diseases. The purpose of this study is to determine if the use of inhaled corticosteroids is associated with suppression of endogenous cortisol production, as seen in patients treated with pharmacologic doses of oral or parenteral steroids.

Detailed Description

The normalcy of the hypothalmic-pituitary-adrenal (HPA) axis of enrolled subjects will be assessed by low dose (1mcg) corticotropin (ACTH)stimulation test. Serum cortisol levels will be measured before , 30 minutes and 60 minutes after 1 mcg ACTH intravenous injection.

Study Timeline

• Study Start: 2007-05
• Study First Submitted: 2007-11-18
• Study First Submitted QC: 2007-11-18
• Study First Posted: 2007-11-20
• Primary Completion: 2007-12
• Study Completion: 2008-12
• Status Verified: 2016-09
• Last Update Submitted: 2016-09-07
• Last Update Posted: 2016-09-08

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• patients receiving inhaled busedonide or fluticasone at daily dose of 200-800 mcg ' for at least 4 weeks

Exclusion Criteria

• patients receiving any corticosteroid therapy, except inhaled busedonide or fluticasone.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
stimulated serum cortisol levels	within 30 days of treatment

Trial Locations

Locations (1)

Endocrine Institute, Haemek medical Center; 🇮🇱 Afula, Israel