The Efficiency of Heated Humidifier High-Flow Nasal Cannula Between Unheated Oxygen Therapy in Difficult Weaning Patients After Extubation in Respiratory Care Center
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Critically Illness
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
- Enrollment
- 80
- Primary Endpoint
- Re-intubation rate
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The purpose of this study is to assess the efficacy of Heated Humidified High-Flow Nasal Cannula compared with noninvasive positive-pressure ventilation in the prevention of extubation failure in patients with prolonged mechanical ventilation.
Detailed Description
There have been many clinical trials comparing the role of Heated Humidified High-Flow Nasal Cannula or Noninvasive positive pressure ventilation in the prevention of extubation failure. These review all have similar results summarized here: Compared with Noninvasive positive pressure ventilation, Heated Humidified High-Flow Nasal Cannula provides better patient comfort, fewer oxygen desaturation episodes, lower likelihood of interface displacement, and, lower reintubation rate than Noninvasive positive pressure ventilation. However, most of these clinical trials focused on participants experiencing acute respiratory failure. Investigators of this study want to find something difference between oh these two groups.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age: Over 20 years of age
- •the requirement of at least six hours of mechanical ventilation per day for at least 14 consecutive days
Exclusion Criteria
- •Pregnancy
- •Status post tracheostomy
- •Neuromuscular diseases
- •Signed "do not resuscitate" order
- •Unplanned extubation
Outcomes
Primary Outcomes
Re-intubation rate
Time Frame: within 72 hours of extubation
Any placement of an endotracheal tube for any indication within 72 hours of extubation, censored at the first of hospital discharge or 72 hours after extubation.
Secondary Outcomes
- Mortality rate(up to 3 months)