The Efficiency of Heated Humidifier High-Flow Nasal Cannula Between Unheated Oxygen Therapy in Difficult Weaning Patients After Extubation in Respiratory Care Center
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 主要终点
- Re-intubation rate
研究概览
简要总结
The purpose of this study is to assess the efficacy of Heated Humidified High-Flow Nasal Cannula compared with noninvasive positive-pressure ventilation in the prevention of extubation failure in patients with prolonged mechanical ventilation.
详细描述
There have been many clinical trials comparing the role of Heated Humidified High-Flow Nasal Cannula or Noninvasive positive pressure ventilation in the prevention of extubation failure.
These review all have similar results summarized here:
Compared with Noninvasive positive pressure ventilation, Heated Humidified High-Flow Nasal Cannula provides better patient comfort, fewer oxygen desaturation episodes, lower likelihood of interface displacement, and, lower reintubation rate than Noninvasive positive pressure ventilation.
However, most of these clinical trials focused on participants experiencing acute respiratory failure.
Investigators of this study want to find something difference between oh these two groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age: Over 20 years of age
- •the requirement of at least six hours of mechanical ventilation per day for at least 14 consecutive days
排除标准
- •Pregnancy
- •Status post tracheostomy
- •Neuromuscular diseases
- •Signed "do not resuscitate" order
- •Unplanned extubation
结局指标
主要结局
Re-intubation rate
时间窗: within 72 hours of extubation
Any placement of an endotracheal tube for any indication within 72 hours of extubation, censored at the first of hospital discharge or 72 hours after extubation.
次要结局
- Mortality rate(up to 3 months)