EUCTR2017-000632-34-FI
Active, not recruiting
Phase 1
Handling oxygenation targets in adults with acute hypoxaemic respiratory failure in the intensive care unit: A randomised clinical trial of a lower versus a higher oxygenation target - Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU)
Department of Anaesthesia and Intensive Care Medicine, Aalborg University Hospital0 sites2,928 target enrollmentFebruary 6, 2018
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Department of Anaesthesia and Intensive Care Medicine, Aalborg University Hospital
- Enrollment
- 2928
- Status
- Active, not recruiting
- Last Updated
- 8 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- Acutely admitted to the intensive care unit AND
- •\- Aged \= 18 years AND
- •\- Receive supplemental oxygen with a flow of at least 10 L per minute in an open system or at least an fraction of inspired oxygen of 0\.50 in a closed system, including invasive ventilation, non\-invasive ventilation or continuous positive airway pressure AND
- •\- Are expected to receive oxygen administration for at least 24 hours in the ICU AND
- •\- Have an arterial line in place
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1\.2 Adults (18\-64 years) yes
- •F.1\.2\.1 Number of subjects for this age range 1312
- •F.1\.3 Elderly (\>\=65 years) yes
Exclusion Criteria
- •\- Cannot be randomised within twelve hours after present ICU admission
- •\- Chronic mechanical ventilation for any reason
- •\- Use of home oxygen
- •\- Previous treatment with bleomycin
- •\- Organ transplant during current hospital admission
- •\- Withdrawal from active therapy or brain death deemed imminent
- •\- Fertile woman with positive urine human gonadotropin (hCG) or
- •plasma\-hCG
- •\- Carbon monoxide poisoning
- •\- Cyanide poisoning
Outcomes
Primary Outcomes
Not specified
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