Intralesional Tetracycline Injection in the Treatment of Chalazia
试验速览
- 阶段
- 早期 1 期
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Lesion size
研究概览
简要总结
The investigators propose a study to investigate the role of tetracycline injection into chalazia versus observation alone. The investigators hypothesize tetracycline injection will result in a significant decrease in lesion size when compared to observation alone.
详细描述
Intralesional Tetracycline Injection in the Treatment of Chalazia
Authors: Bryan R. Costin, M.D. and Julian D. Perry, M.D.
Purpose: To investigate the therapeutic role of intralesional tetracycline injection when compared to observation alone in the treatment of chalazia.
Introduction:
The tetracycline family includes tetracycline, doxycycline, and minocycline and this group of compounds has a surprising number of properties including but not limited to antibiotic, anti-malarial, anti-inflammatory, and antioxidant. Recent applications include uses both in sclerotherapy in a wide variety of conditions from ganglions cysts to lymphangiomas to ovarian cysts as well as in the reduction of hypertrophic scarring in rabbit models.1,2,3,4 In 2009, there were approximately 130 ongoing clinical trials studying this class of drugs in an astounding variety of conditions from gingivitis to Alzheimer disease to brain cancer.5
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age older than 18 years
- •Not pregnant
- •Chalazia of greater than 1 week duration
- •Not allergic to tetracycline or its derivatives
- •Not currently taking tetracycline or not taking them in the past 3 months
排除标准
- •Age less than 18 years old
- •Pregnancy
- •Chalazia of less than 1 week duration
- •Allergies to tetracycline or its derivatives
- •Currently taking tetracyclines or have taken them in the past 3 months
研究组 & 干预措施
Tetracycline
30 patients will be randomized to treatment with an intralesional injection of 0.05 mL of 2% tetracycline solution. These subjects will return 4 weeks (+/- 2 weeks) after treatment for lesion measurement and photographs.
干预措施: Tetracycline (Drug)
结局指标
主要结局
Lesion size
时间窗: 4 weeks
The size of the lesion will be measured as well as photographed. Photographs will be reviewed by a masked chalazion photograph reviewer.
次要结局
未报告次要终点