Monitoring of Progesterone Administered in Infertile Patients During a Cycle of Frozen Embryo Transfer.
Not Applicable
Recruiting
- Conditions
- IVF
- Registration Number
- NCT05109676
- Lead Sponsor
- University Hospital, Toulouse
- Brief Summary
During an In Vitro Fertilization (IVF) attempt, several embryos are obtained but not all of them can be transferred to the uterus in the same cycle due to the risk of multiple pregnancies. Thus, it is very common for these couples to benefit from cryopreservation. Patients scheduled for frozen embryo transfer (TEC) receive estrogen and progesterone replacement therapy to prepare the endometrium for implantation. Data from the literature recently showed that low progesterone on the day of embryo transfer was responsible for a significantly higher rate of implantation failure and miscarriage.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 200
Inclusion Criteria
- Adult patient undergoing a frozen embryo transfer in an artificial cycle at the AMP center of the Toulouse University Hospital.
- Affiliation to a social security scheme or equivalent
- Patient fulfilling the conditions for access to the AMP according to French bioethics law
- Patient having given her consent (oral or written) after clear and fair information
Exclusion Criteria
- Patient who received intramuscular administration of progesterone during the endometrial preparation phase.
- Patient with comprehension difficulties.
- Protected adult patient (safeguard of justice, guardianship or curatorship)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Average plasma progesterone concentration. Day of embryo transfer. Dosage of apparent clearance (CL/F)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CHU Toulouse
🇫🇷Toulouse, France
CHU Toulouse🇫🇷Toulouse, FranceNicolas GatimelPrincipal Investigator