Is Long-Term Proton Pump Inhibitor Use a Cause of Leaky Gut Syndrome
- Conditions
- Proton Pump Inhibitor Adverse Reaction
- Interventions
- Diagnostic Test: Blood for zonulin level was drawn from the group.
- Registration Number
- NCT06268834
- Lead Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
- Brief Summary
Our study aims to investigate the effect of bacterial overgrowth induced by long-term PPI use on zonulin levels.
- Detailed Description
The study included a total of 75 participants, with 45 individuals classified as long-term PPI users and 30 as non-PPI users. The PPI user group was defined as those who had been consistently using PPIs (specifically omeprazole, lansoprazole, pantoprazole, esomeprazole, or rabeprazole) on a daily basis for a minimum of 6 months or at least twice a week for a minimum of 2 years. The control group comprised individuals who had never used PPIs. Venous blood samples were taken from all participants to measure serum zonulin levels.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 75
The patient group was patients taking long-term PPIs (omeprazole, lansoprazole, pantoprazole, esomeprazole and rabeprazole) every day for at least 6 months or at least twice a week for at least 2 years.
A control group was formed from individuals who had never used PPI.
Those with inflammatory bowel disease, celiac disease, type 1 diabetes, active gastroenteritis, acute kidney failure, chronic kidney failure, and those who had used antibiotics for any reason in the last 3 months, as well as those receiving probiotic drug support, were not included in the study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Using PPI Blood for zonulin level was drawn from the group. Group receiving a long-term PPI (omeprazole, lansoprazole, pantoprazole, esomeprazole and rabeprazole) every day for at least 6 months or at least twice a week for at least 2 years. Control Blood for zonulin level was drawn from the group. A control group was formed from individuals who had never used PPI.
- Primary Outcome Measures
Name Time Method Zonulin levels in long-term proton pump inhibitor users Blood was drawn and collected during the examination and studied collectively after 3 months Approximately 5 cc of blood was drawn from the antebrachial veins of the patients to determine serum zonulin levels. Serum örnekleri -80 santigrat derecede 3 ay süreyle saklanmıştır. Serum örneklerindeki Zonulin seviyeleri Shanghai Crystal Day Biotech Co, Ltd, Shanghai, Çin'den ticari BT-LAB Human Zonulin ELISA kitleri (Kat. No. E1117Hu) kullanılarak ölçülmüştür. The test range of the kit was 2-600 ng/ml. The sensitivity of the test was 1.09 ng/ml. A serum zonulin level above 12 ng/ml was considered positive.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital
🇹🇷Ankara, Turkey