Lack of Acute Tolerance Development to Effects of Nitrous Oxide
Overview
- Phase
- Phase 2
- Intervention
- 10% N2O
- Conditions
- Opioid-Related Disorders
- Sponsor
- University of Chicago
- Enrollment
- 11
- Locations
- 1
- Primary Endpoint
- Psychomotor performance
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine the lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
10% N2O
Subjects will inhale 10% N2O
Intervention: 10% N2O
20% N2O
Subjects will inhale 20% N2O
Intervention: 20% N2O
30% N2O
Subjects will inhale 30% N2O
Intervention: 30% N2O
40% N2O
Subjects will inhale 40% N2O
Intervention: 40% N2O
0% N2O
Subjects will inhale 0% N2O
Intervention: 0% N2O
Outcomes
Primary Outcomes
Psychomotor performance
Time Frame: During inhalation
Subjects will undergo psychomotor testing during 120 min inhalation session of each intervention
Cognitive performance
Time Frame: During inhalation
Subjects will under cognitive testing during 120 minute inhalation session of each intervention