Differential Acute Tolerance Development to Effects of Nitrous Oxide - 7

Phase 2

Completed

• Conditions: Substance-Related Disorders; Opioid-Related Disorders
• Interventions: Drug: Nitrous oxide

• Registration Number: NCT00000255
• Lead Sponsor: University of Chicago

Brief Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine differential acute tolerance development to effects of nitrous oxide in humans.

Detailed Description

Not available

Study Timeline

• Study Start: 1995-04
• Primary Completion: 1996-05
• Study Completion: 1996-05
• Study First Submitted: 1999-09-20
• Study First Submitted QC: 1999-09-20
• Study First Posted: 1999-09-21
• Status Verified: 2015-05
• Last Update Submitted: 2015-05-26
• Last Update Posted: 2015-05-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
30% nitrous oxide	Nitrous oxide	-
20% nitrous oxide	Nitrous oxide	-
0% Nitrous oxide	Nitrous oxide	-
10% nitrous oxide	Nitrous oxide	-
40% nitrous oxide	Nitrous oxide	-

Primary Outcome Measures

Name	Time	Method
Pain intensity, pain bothersomeness	25, 70, & 115 min of inhalation and 40 min post	Subjects will inhale varying conc of nitrous oxide for 120 min with cold immersion of forearm at 25, 70, and 115 min and 40 min after inhalation. Pain intensity and bothersomeness will be assessed at each immersion.

Trial Locations

Locations (1)

University of Chicago, Anesthesia & Critical Care; 🇺🇸 Chicago, Illinois, United States