Differential Acute Tolerance Development to Effects of Nitrous Oxide
Overview
- Phase
- Phase 2
- Intervention
- Nitrous oxide
- Conditions
- Opioid-Related Disorders
- Sponsor
- University of Chicago
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Pain intensity, pain bothersomeness
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine differential acute tolerance development to effects of nitrous oxide in humans.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
30% nitrous oxide
Intervention: Nitrous oxide
20% nitrous oxide
Intervention: Nitrous oxide
0% Nitrous oxide
Intervention: Nitrous oxide
10% nitrous oxide
Intervention: Nitrous oxide
40% nitrous oxide
Intervention: Nitrous oxide
Outcomes
Primary Outcomes
Pain intensity, pain bothersomeness
Time Frame: 25, 70, & 115 min of inhalation and 40 min post
Subjects will inhale varying conc of nitrous oxide for 120 min with cold immersion of forearm at 25, 70, and 115 min and 40 min after inhalation. Pain intensity and bothersomeness will be assessed at each immersion.