跳至主要内容
临床试验/CTRI/2024/06/069260
CTRI/2024/06/069260尚未招募不适用

Correlation of Anthropometry with Left Ventricular Mass in Normal Rural Children

Datta Meghe Institute of Higher Education and Research1 个研究点 分布在 1 个国家目标入组 29 人开始时间: 2024年6月30日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
29
试验地点
1
主要终点
To find out correlation between anthropometry and left ventricle mass in normal healthy rural children

研究概览

简要总结

After obtaining the informed consent from the parents/guardians children will be included in the study. All normal rural children who come under school health checkup at AVBRH Sawangi, Meghe, Wardha will be included. The design of this study will be a descriptive, cross sectional study. All children will beselected as per inclusion criteria and will be subjected to echocardiography. The demographic data, age and gender of the child will be assessed. According to the detailed history anddiagnosis, all children will be subjected to physical and routine lab investigations. Subjects will be included if they do not have cardiac disease or a history of heart involvement due to infections, neuromuscular or metabolic disorders. The age (in months), weight (Wt) in kilograms (Kg), and the height (Ht) in centimeters (cm) will be obtained. The body surface area (BSA) in square meters (m2 )will be calculated by using the DuBois & DuBois (1916) formula as the following equation: BSA (m2 ) = (0.0001) (71.84) (Wt0.425) (Ht0.725)

 Transthoracic echocardiographic examination will be performed with the child lying supine or in the left lateral semirecumbent position. No sedation will be used during echocardiography. Twodimensional and M-mode echocardiographic studies will be carried out by a single pediatric cardiologist using a commercially available machine (GE Echocardiography Versana). The two dimensional image will be used to obtain the optimum position and angulation of the M-mode line. Standard parasternal, apical, subcostal and suprasternal views will be used. The end-diastolic left ventricular internal dimension (LVIDd), end-diastolic left ventricular posterior wall thickness (LVPWd) and end-diastolic interventricular septum (IVSd)) values will be determined by echocardiographic examination. Left ventricular mass will be calculated by the formula of Devereux et al. (1986) which has been validated for use in children with normal hearts: LVM (g)=0.8 {1.04((IVST+LVID+LVPWT)3 –LVID3)} +0.6

The children will be divided into 6 groups according to their BSA: 0.20-0.25 m2 , 0.25-0.50 m2 , 0.50-0.75 m2 , 0.75-1.0 m2 , 1.0-1.25 m2 , and 1.25-1.50 m2 . The means, ±SD of LVIDd, LVPWd, IVSd, LVM and LVM/BSA values will be estimated for all groups.

**Aim:**To find out the correlation between Anthropometry with Left Ventricular Mass in Normal Rural Children.

研究设计

研究类型
Observational

入排标准

年龄范围
5.00 Year(s) 至 15.00 Year(s)(—)
性别
All

入选标准

  • Normal healthy rural children aged 5 to 15 years.

排除标准

  • Child with congenital malformation Syndromic child Severe Acute Malnutrition Any comorbidities.

结局指标

主要结局

To find out correlation between anthropometry and left ventricle mass in normal healthy rural children

时间窗: At baseline

次要结局

  • To investigate sex differences with left ventricle mass(At baseline)
  • To find out correlation between blood pressure & left ventricular mass(At baseline)

研究者

发起方
Datta Meghe Institute of Higher Education and Research
申办方类型
Other [Datta Meghe Institute of Higher Education and Research]
责任方
Principal Investigator
主要研究者

Dr Astha Khurana

Datta Meghe Institute of Higher Education and Research

研究点 (1)

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