The Impact of the Time of Day on Metabolic Responses to Resistance Exercise in Adults Who Are Obese or Overweight: a Randomised Controlled Trial

University of Glasgow1 site in 1 country36 target enrollmentMay 1, 2022

ConditionsMetabolic Disease

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Metabolic Disease
Sponsor: University of Glasgow
Enrollment: 36
Locations: 1
Primary Endpoint: Change in insulin sensitivity
Status: Completed
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The aim of the current study is to determine the effect of time of day on the muscle and metabolic responses to resistance exercises in obese or overweight adults. To achieve this aim we have the following objectives:

Compare the effects of resistance exercise training performed in the morning vs the evening on insulin sensitivity
Compare the effects of resistance exercise training performed in the morning vs the evening on gains in muscle mass and strength
Compare the acute glucose responses to resistance exercise performed in the morning vs the evening

Registry

clinicaltrials.gov

Start Date

May 1, 2022

End Date

February 1, 2024

Last Updated

last year

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University of Glasgow

Responsible Party

Principal Investigator

Stuart Gray

Senior Lecturer

University of Glasgow

Eligibility Criteria

Inclusion Criteria

•pass the physical activity readiness questionnaire
•body mass index (BMI) \>27kg/m² and limited to 40 kg/m².

Exclusion Criteria

•Prior surgery for weight loss
•Prior history of heart, lung, cancer, endocrine or liver disease
•Participating in more than 1 hour structured exercise training per week

Outcomes

Primary Outcomes

Change in insulin sensitivity

Time Frame: Change from baseline to 6 weeks

Insulin sensitivity calculated via the Matsuda Index during an oral glucose tolerance test

Secondary Outcomes

Change in vastus lateralis muscle thickness(Change from baseline to 6 weeks)
Change in whole body lean mass(Change from baseline to 6 weeks)
Change in whole body fat mass(Change from baseline to 6 weeks)
Change in one-repetition maximum muscle strength(Change from baseline to 6 weeks)
Change in knee extensor maximal isometric torque(Change from baseline to 6 weeks)
Change in grip strength(Change from baseline to 6 weeks)
Change in mean glucose levels(Change from baseline to 6 weeks)
Change in glucose variability(Change from baseline to 6 weeks)