NL-OMON45194
Completed
Not Applicable
Reduction of antibiotic therapy by biomarkers in patients with CAP episodes - REDUCE study
Medisch Centrum Alkmaar0 sites468 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pneumonia
- Sponsor
- Medisch Centrum Alkmaar
- Enrollment
- 468
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Male and female patients with a diagnosis of CAP and all criteria listed below:
- •1\. Age 18 or above, no upper age limit will be employed.
- •2\. Patients must require hospitalisation.
- •3\. Clinical presentation of an acute illness with one or more of the following symptoms:
- •a. Temperature \* 38\.0 \*C (100\.4°F)
- •b. Dyspnoea
- •c. Cough (with or without expectoration of sputum)
- •d. Chest pain
- •e. Hemoptysis
- •f. Malaise or fatigue
Exclusion Criteria
- •Subjects presenting with any of the following will not be included in the study:
- •1\. Severe immunosuppression (HIV infection, chemotherapy).
- •2\. Active neoplastic disease.
- •3\. Obstruction pneumonia (e.g. from lung cancer).
- •4\. Aspiration pneumonia.
- •5\. Pneumonia that developed within 8 days after hospital discharge.
- •6\. Unable and/or unlikely to comprehend and/or follow the protocol.
- •7\. Pregnant and/or lactating women.
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Not Applicable
Biomarkers for prediction of antibiotics induced changes and recovery of the oral and intestinal microbiome (Biopam)DRKS00020811Klinikum der Universität München8
Completed
Not Applicable
Biomarkers to target antibiotics and steroid therapy in chronic obstructive pulmonary disease (COPD) exacerbationsISRCTN92422949niversity Hospitals of Leicester NHS Trust (UK)106
Active, not recruiting
Phase 1
Biomarkers and treatment of pneumonia.EUCTR2015-002501-11-DKordsjællands Hospital300
Not yet recruiting
Phase 4
Is antibiotic treatment associated with reduced risk of a subsequent exacerbation and mortality in chronic obstructive lung disease? A randomized clinical trial.Exacerbation COPD10004018NL-OMON36745Academisch Medisch Centrum2,000
Recruiting
Phase 3
The effect of antibiotic therapy on the results of biopsy in meProstate Cancer.Malignant neoplasm of prostateIRCT20180915041037N1Yazd University of Medical Sciences80