ISRCTN92422949
Completed
Not Applicable
The use of biomarkers to direct antibiotic and systemic corticosteroid therapy in chronic obstructive pulmonary disease (COPD) exacerbations: a randomised controlled study
niversity Hospitals of Leicester NHS Trust (UK)0 sites106 target enrollmentJuly 30, 2009
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- niversity Hospitals of Leicester NHS Trust (UK)
- Enrollment
- 106
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Provision of informed consent
- •2\. Male or female
- •3\. Aged 40 years or over
- •4\. Diagnosis of COPD
- •5\. Greater than one exacerbation requiring antibiotics and or corticosteroids in the preceding year
Exclusion Criteria
- •1\. Current active respiratory tuberculosis
- •2\. Upon questioning the patient known human immunodeficiency virus (HIV) infection or positive hepatitis B or C
- •3\. Known inability to produce a sputum sample during the induced sputum procedure
- •4\. Clinically relevant disease or disorder (past or present) which in the opinion of the investigator may either put the subject at risk because of participating in the study or may influence the results of the study or the subject's ability to participate in the study
- •5\. Any clinically relevant lung disease other than COPD
- •6\. Donation of blood within 3 months or during the study (for other than study purpose)
- •7\. Pregnancy or lactation
Outcomes
Primary Outcomes
Not specified
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