Functional Hip Strength and Pain Changes in Women With Knee Osteoarthritis Following a Single-Dose Intra-Articular Platelet-Rich Plasma Injection and a 6-Week Home Exercise Program: A Single-Group Longitudinal Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 27
- 试验地点
- 1
- 主要终点
- Hip Stability Isometric Test (HipSIT) strength (N/kg), affected side
研究概览
简要总结
This single-group longitudinal study evaluated changes in hip stability isometric strength, knee muscle strength, and activity-related pain in women with knee osteoarthritis following a single-dose intra-articular platelet-rich plasma (PRP) injection and a 6-week home exercise program. Outcomes were assessed at baseline (5 days post-injection), week 6, and week 12. The intervention included strengthening exercises for knee and hip muscle groups performed three times per week and regular walking encouragement with weekly phone follow-up for adherence.
详细描述
Participants with unilateral symptomatic knee osteoarthritis performed a standardized 6-week home strengthening program (knee extensors/flexors; hip extensors/abductors/external rotators) three times weekly and were encouraged to walk regularly. Hip Stability Isometric Test (HipSIT), quadriceps/hamstring strength (hand-held dynamometry, normalized to body mass), and activity pain (VAS 0-10) were measured at baseline, week 6, and week 12 to evaluate functional strength and symptom changes after PRP plus exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Female patients aged 45-70 years.
- •Radiographic knee osteoarthritis: Kellgren-Lawrence grade II-III in the affected knee and grade II or less in the unaffected knee.
- •Unilateral knee pain during activity with VAS score ≥5 (for at least the past 3 months).
- •Referred to physiotherapy following a unilateral single-dose PRP injection.
排除标准
- •Any intra-articular knee injection within the past 6 months.
- •Regular lower-extremity strengthening exercise or non-pharmacological treatment for knee OA within the past 6 weeks.
- •History of lower-extremity surgery.
- •History of neurological, rheumatological and/or cognitive diseases.
- •Unable to use a telephone.
研究组 & 干预措施
Single Group: PRP Injection + Home Exercise Program
All participants received a unilateral single-dose intra-articular platelet-rich plasma (PRP) injection for symptomatic knee osteoarthritis, followed by a 6-week home-based strengthening and functional exercise program performed 3 times per week. The exercise program targeted knee extensors/flexors and hip extensors/abductors/external rotators. Participants were encouraged to walk at least 30 minutes on at least 5 days per week and were contacted weekly by phone to support adherence.
干预措施: Platelet-Rich Plasma (PRP) Injection (Biological)
Single Group: PRP Injection + Home Exercise Program
All participants received a unilateral single-dose intra-articular platelet-rich plasma (PRP) injection for symptomatic knee osteoarthritis, followed by a 6-week home-based strengthening and functional exercise program performed 3 times per week. The exercise program targeted knee extensors/flexors and hip extensors/abductors/external rotators. Participants were encouraged to walk at least 30 minutes on at least 5 days per week and were contacted weekly by phone to support adherence.
干预措施: Home Exercise Program (Behavioral)
结局指标
主要结局
Hip Stability Isometric Test (HipSIT) strength (N/kg), affected side
时间窗: Baseline (5 days post PRP injection), Week 6, Week 12
Hip stability isometric strength (combined hip extensor, abductor and external rotator maximum isometric strength) assessed using a hand-held dynamometer during the Hip Stability Isometric Test (HipSIT). The test is performed in side-lying "clam" position (hip 45° flexion, knee 90° flexion). Three maximal trials (5 seconds each) are performed and the maximum force output (N) is normalized to body mass (N/kg).
次要结局
- Quadriceps femoris isometric strength (N/kg), affected side(Baseline (5 days post PRP injection), Week 6, Week 12)
- Hamstring isometric strength (N/kg), affected side(Baseline (5 days post PRP injection), Week 6, Week 12)
- Knee pain during activity (Visual Analog Scale, 0-10)(Baseline (5 days post PRP injection), Week 6, Week 12)
研究者
Muharrem Gökhan Beydağı
Assistant Professor
Firat University