MedPath

STUDY ON EFFECT OF COLD SALINE IRRIGATION ON POSTOPERATIVE PAIN AFTER ROOT CANAL TREATMENT

Phase 3
Recruiting
Conditions
Acute apical periodontitis of pulpal origin,
Registration Number
CTRI/2022/10/046599
Lead Sponsor
Dr snehal shelke
Brief Summary

Pain is an unwanted yet unfortunately common sensation after root canaltreatment. which commences a few hours or days after treatment and is always anunpleasant experience for both patients and clinicians.In 2016, cryotherapy was first clinically used in endodontics by Keskin etalfor minimizing postoperative pain after single-visit root canaltreatment. Their study included teeth with vital inflamed pulps; however, theydid not differentiate between asymptomatic and symptomatic pulpitis nor didthey differentiate between cases with and without apical periodontitis.Other studies following the same protocol presented by Vera et alaffirmedthat cryotherapy reduced postoperative pain after single-visit root canal treatmentin teeth with vital pulps.Nevertheless, extirpation of theinflamed pulp in irreversible pulpitis where the inflammation is confinedwithin the pulp and did not extend into the periapical tissue is usually proceededby patient relief so the direct effect ofcryotherapy on reducing postoperative pain could not be established in thiscase.Therefore the purpose ofthis study is to evaluate and compare the effect of cryotreated saline and roomtemperature saline as a final irrigant on pain after single visit root canaltreatment in patients with vital inflamed pulp with apical periodontitis.

Detailed Description

Not available

Recruitment & Eligibility

Status
Open to Recruitment
Sex
All
Target Recruitment
60
Inclusion Criteria
  • The age group of 18–50 years who signed the informed consent.
  • The patient requiring endodontic therapy.
  • Mandibular premolars diagnosed with symptomatic irreversible pulpitis with apical periodontitis.
  • Healthy patients without any systemic disease.
  • Patients with pain score ranging from moderate to severe (4–10) on a visual analog scale (VAS).
Exclusion Criteria
  • Patients who are medically compromised.
  • Pregnant patients.
  • Teeth with incomplete apex formation.
  • Teeth with calcified canals.
  • Teeth with Sinus opening.
  • Teeth with periapical abscess.
  • Patients on antibiotic therapy.
  • Patients on analgesics on the day of treatment.

Study & Design

Study Type
Interventional
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
reduction in postoperative painreduction in postoperative pain after 6 hours,12 hours,24 hours,48 hours and 1 week
Secondary Outcome Measures
NameTimeMethod
pain reduction in intervention group when compared to control group using visual analouge scale.6 hours,12hours,24 hours,48 hours,1 week

Trial Locations

Locations (1)

Government Dental College and Hospital,Nagpur

🇮🇳

Nagpur, MAHARASHTRA, India

Government Dental College and Hospital,Nagpur
🇮🇳Nagpur, MAHARASHTRA, India
dr snehal shelke
Principal investigator
9404352227
snehalshelke3@gmail.com

MedPath

Empowering clinical research with data-driven insights and AI-powered tools.

© 2025 MedPath, Inc. All rights reserved.