Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome
Not Applicable
Recruiting
- Conditions
- Obstructive Sleep Apnea Syndrome
- Interventions
- Diagnostic Test: functional magnetic resonance imaging
- Registration Number
- NCT05147649
- Lead Sponsor
- CHU de Reims
- Brief Summary
The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration. UA collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory loading in normal subjects elicits respiratory-related cortical activity during wakefulness. The objective of this study is to test whether awake OSAS patients would exhibit a similar cortical activity. Whether or not such cortical compensatory mechanisms have cognitive consequences would be also analyze.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 70
Inclusion Criteria
Not provided
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Exclusion Criteria
Not provided
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description OSAS patients functional magnetic resonance imaging Patients with severe OSAS with an Apnea-Hypopnea Index (AHI) \> 30/h non-OSAS patients functional magnetic resonance imaging Patients without OSAS (Apnea-Hypopnea Index (AHI) \< 15/h and absence of excessive daytime sleepiness with Epworth score \<11)
- Primary Outcome Measures
Name Time Method Premotor cortex activation in OSAS patients without CPAP Day 0
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Chu Reims
🇫🇷Reims, France