Relationship Between Obstructive Sleep Apnea and Coronary Atherosclerosis

Completed

• Conditions: Coronary Artery Disease; Obstructive Sleep Apnea

• Registration Number: NCT01306526
• Lead Sponsor: National University of Singapore

Brief Summary

Obstructive sleep apnea (OSA) is a respiratory disorder of sleep characterized by recurrent episodes of complete or partial upper airway obstruction, leading to intermittent oxygen deprivation. This results in sympathetic activation and surges in blood pressure, production of vasoactive substances, as well as activation of the inflammatory and procoagulant pathways. Epidemiological evidence indicates the prevalence of OSA is higher in patients with coronary artery disease than in the general population. The investigators recently showed that 65.7% and 41.9% of the Singapore patients admitted with myocardial infarction were found to have previously undiagnosed OSA and severe OSA, respectively. In a 10-year follow-up epidemiological study, OSA was independently associated with a higher prevalence of fatal and non-fatal cardiovascular events among the otherwise healthy general population. The investigators further showed that in patients who have undergone primary percutaneous coronary intervention for acute myocardial infarction, OSA was an independent predictor of future adverse event rates. Despite the observed association between OSA and adverse cardiovascular outcomes, the underlying pathophysiological mechanisms remain unclear. In this proposal, the investigators aim to elucidate the relationship between OSA and composition of coronary atherosclerotic plaques.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-02
• Study First Submitted: 2011-03-01
• Study First Submitted QC: 2011-03-01
• Study First Posted: 2011-03-02
• Primary Completion: 2013-01
• Study Completion: 2013-03
• Status Verified: 2014-01
• Last Update Submitted: 2014-01-07
• Last Update Posted: 2014-01-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 118

Inclusion Criteria

• Angiogrqaphically documented coronary artery disease
• De novo lesion
• Native coronary artery

Exclusion Criteria

• known OSA
• intubation and mechanical ventilation
• electrical instability with a high risk of malignant ventricular arrhythmia
• cardiogenic shock
• previous coronary artery bypass surgery
• chronic renal failure on dialysis
• inability to give informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total Atheroma Volume	Baseline	Relationship between OSA and Total Atheroma Volume determined (IVUS) will be determined

Secondary Outcome Measures

Name	Time	Method
Thin-cap fibroatheroma	Baseline	Relation between OSA and prevalence of thin-cap fibroatheroma (VH-IVUS) will be determined

Trial Locations

Locations (1)

National University Health System; 🇸🇬 Singapore, Singapore