Diurnal Evaluation of OSA Upper Airway Collapsibility and Muscle Responsiveness

Recruiting

• Conditions: Obstructive Sleep Apnea

• Registration Number: NCT06334601
• Lead Sponsor: Istituto Auxologico Italiano

Brief Summary

In the framework of pathophysiological trait in obstructive sleep apnea (OSA) patients, a simplified method is proposed to measure upper airway (UA) collapsibility and muscle responsiveness during wakefulness.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-15
• Study First Submitted: 2024-03-19
• Study First Submitted QC: 2024-03-25
• Study First Posted: 2024-03-28
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-29
• Last Update Posted: 2025-04-30
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

• Obstructive Sleep Apnea (OSA)
• At home-polygraphy with at least one EEG channel (PSG) reporting moderate-to severe obstructive sleep apnea (apnea-hypopnea index >14).

Exclusion Criteria

• OSA treatment ongoing during two weeks before PSG
• Unstable cardio-respiratory disease in the 3 months before enrollment
• Subjects in O2 treatment

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Upper airway muscle responsiveness	During the diagnostic test	Evaluation during wakefulness
Upper airway collapsibility	During the diagnostic test	Evaluation during wakefulness

Trial Locations

Locations (1)

IRCCS Istituto Auxologico Italiano,Ospedale San Luca; 🇮🇹 Milano, Italy