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临床试验/NCT05404269
NCT05404269已完成不适用

Comparison of AGC (Automatic Gas Control) Mode and Manually Controlled Minimal Flow Anesthesia in Breast Surgery

Zonguldak Bulent Ecevit University1 个研究点 分布在 1 个国家目标入组 90 人开始时间: 2021年3月15日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
90
试验地点
1
主要终点
Consumption of Volatile Agent

研究概览

简要总结

The aim of this study was to compare the AGC mode and manually controlled minimal-flow anesthesia for volatile anesthetic consumption, hemodynamic parameters, and recovery from anesthesia

详细描述

Modern anesthesia machines use circular systems in which ventilated gas re-circulates to a certain degree and is therefore reused, preserving temperature, and humidity. The rebreathing fraction is increased by a reduction in fresh gas flow, which leads to a considerable decrease in consumption of fresh gas and volatile anesthetics, resulting in reductions in cost and atmospheric pollution. In a closed ventilation system, only the patient's requirements for oxygen and anesthetic agents are supplemented. A fresh gas flow-rate of 0.5 l/min is defined as the minimal-flow technique. The oxygen and anesthetic gas titration can be manually controlled by the anesthetist. To assure safe and appropriate anesthesia, manually controlled anesthesia requires constant monitoring and numerous adjustments to the gas dosage by the anesthetist, especially for low- and minimalflow anesthesia. Oxygen flow and volatile anesthetics can also be automatically controlled by anesthesia machines using end-tidal control (such as AGC mode of Maquet FLOW-i anesthesia machine), which ensures constant end-tidal concentration of oxygen and anesthetic gas via feedback and continuous automatic adjustment mechanisms. Anesthesiologists needing to make fewer interventions during a case may have clinical importance in terms of distraction, record keeping and patient safety. In addition to this advantage, we wanted to compare the AGC mode and manually controlled minimal-flow anesthesia for volatile anesthetic consumption, hemodynamic parameters, and recovery from anesthesia.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
Female
接受健康志愿者

入选标准

  • 18-65 years
  • undergoing breast surgery
  • ASA physical status I-II
  • operation lasting at least 1 hour
  • those who agreed to volunteer for the study with an informed consent form

排除标准

  • coronary artery disease, CHF
  • pregnancy or breastfeeding women
  • decompensated diabetes mellitus
  • kidney or liver failure
  • chronic obstructive pulmonary disease
  • opioid sensitivity
  • history of malignant hyperthermia
  • history of smoking
  • alcohol or drug addiction
  • significant anemia
  • patients with allergies to the drugs used in the study

结局指标

主要结局

Consumption of Volatile Agent

时间窗: during the surgery

Difference of Sevoflurane Consumption between the groups

次要结局

未报告次要终点

研究者

发起方
Zonguldak Bulent Ecevit University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Gökhan Çeviker

Anesthesiologist

Zonguldak Bulent Ecevit University

研究点 (1)

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