Global Electrical Heterogeneity and Clinical Outcomes
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Heart Failure
- 发起方
- Larisa Tereshchenko
- 入组人数
- 3471
- 试验地点
- 6
- 主要终点
- Primary competing outcome: All-cause death without preceding sustained VT/VF with appropriate ICD therapy
- 状态
- 已完成
- 最后更新
- 4年前
概览
简要总结
This retrospective multicenter cohort will validate an independent association of electrocardiographic (ECG) global electrical heterogeneity (GEH) measures with sustained ventricular tachyarrhythmias and appropriate ICD therapies in systolic heart failure patients with primary prevention ICD, and will validate and re-calibrate GEH ECG risk score for prediction of sustained ventricular tachyarrhythmias and appropriate ICD therapies in systolic heart failure patients with primary prevention ICD.
研究者
Larisa Tereshchenko
Associate Professor of Medicine
Oregon Health and Science University
入排标准
入选标准
- •records of systolic heart failure patients with primary prevention ICDs/CRT-Ds implanted for routine clinical indications
排除标准
- •absent baseline pre-implant digital ECG;
- •missing data on clinical predictors and covariates;
- •missing ICD programming data (including number of intervals to detect \[NID\] or time to detect, number of detection zones, heart rate for each detection zone, and anti-tachycardia pacing \[ATP\] programming);
- •missing outcomes data.
- •records of patients with inherited channelopathies (e.g. long QT syndrome, Brugada syndrome), inherited cardiomyopathies (e.g. hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy), and congenital heart disease.
结局指标
主要结局
Primary competing outcome: All-cause death without preceding sustained VT/VF with appropriate ICD therapy
时间窗: up to 15 years
All-cause death without preceding sustained ventricular tachyarrhythmia with appropriate ICD therapy
Primary outcome: sustained VT/VF event with appropriate ICD therapy (either ATP or shock)
时间窗: up to 15 years
Sustained ventricular tachyarrhythmia event with appropriate ICD therapy (either antitachycardia pacing or shock)
次要结局
- sustained polymorphic ventricular tachycardia / ventricular fibrillation(up to 15 years)
- sustained monomorphic ventricular tachycardia(up to 15 years)