Comprehensive Evaluation of Scoliosis and Its Association With Functional Status, Postural Alignment, and Disease Activity in Children With Juvenile Idiopathic Arthritis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 200
- 主要终点
- Prevalence of Scoliosis in Children With Juvenile Idiopathic Arthritis
研究概览
简要总结
Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease that may affect musculoskeletal development and posture in children. Spinal involvement, including scoliosis, is not routinely evaluated in clinical practice despite its potential impact on functional status and quality of life.
This cross-sectional study aims to assess the presence of scoliosis in children with JIA and to investigate its association with functional status, postural alignment, and disease activity. Clinical and functional parameters will be analyzed to better understand the impact of spinal deformities in this population.
详细描述
Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease that may negatively affect musculoskeletal development, posture, and overall physical function in children. Although peripheral joint involvement is well characterized, axial and postural abnormalities, including scoliosis, are not routinely assessed during follow-up despite their potential clinical significance.
This cross-sectional study aims to evaluate the presence of scoliosis in children with JIA and to investigate its relationship with disease activity, functional status, pain, and postural alignment. Comprehensive clinical assessments, including physical examination, disease activity scores, and functional evaluation tools, will be performed. Where applicable, postural analysis and imaging findings will also be considered.
By identifying the frequency and clinical impact of scoliosis in JIA, this study seeks to improve awareness of spinal involvement and to provide a basis for early recognition and multidisciplinary management strategies, including targeted physiotherapy interventions.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 8 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 8 to 18 years at the time of enrollment.
- •Diagnosis of juvenile idiopathic arthritis (JIA) according to ILAR criteria.
- •Followed at the study center and able to complete clinical and functional assessments during a single study visit.
- •Availability of standing spinal radiographs suitable for Cobb angle measurement (performed per standard of care or obtained during study procedures, as applicable).
- •Written informed consent from parent/legal guardian and assent from the child/adolescent when appropriate.
排除标准
- •Known scoliosis due to non-JIA causes, including congenital vertebral anomalies, neuromuscular disorders, or syndromic scoliosis.
- •Prior spinal surgery or current brace treatment for scoliosis
- •History of significant spinal trauma or spinal infection/tumor affecting spinal alignment.
- •Coexisting chronic conditions that substantially affect posture/gait or functional testing (e.g., severe neurologic impairment) and would confound functional assessments.
- •Inability to undergo required assessments (e.g., unable to stand for radiograph or complete functional measures).
研究组 & 干预措施
JIA Patients With Scoliosis
Children diagnosed with juvenile idiopathic arthritis (JIA) who have scoliosis, defined by a Cobb angle of ≥10 degrees on standing spinal radiographs. Clinical characteristics, disease activity parameters, and functional assessments including postural and plantar pressure analyses will be evaluated. No intervention will be applied; this group will be observationally assessed.
JIA Patients Without Scoliosis
Children diagnosed with juvenile idiopathic arthritis (JIA) without evidence of scoliosis (Cobb angle <10 degrees). Participants will undergo the same clinical, laboratory (if applicable), and functional assessments as the scoliosis group. This is an observational group with no intervention.
结局指标
主要结局
Prevalence of Scoliosis in Children With Juvenile Idiopathic Arthritis
时间窗: At baseline (single study visit)
Proportion of participants with scoliosis, defined as a Cobb angle ≥10° measured on standing spinal radiographs.
次要结局
- Scoliosis Severity (Cobb Angle)(At baseline (single study visit))
- Health-Related Quality of Life (PedsQL)(At baseline (single study visit))
研究者
Bengisu Menentoğlu
MD
Istanbul University