The BASA Study: Breath Analysis for Severe Asthma Patients
Recruiting
- Conditions
- Severe Asthma
- Registration Number
- NCT05946421
- Lead Sponsor
- Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo
- Brief Summary
This study will evaluate the fluctuations of exhaled breath markers in patients with severe asthma on biologics. In the study, severe asthma patients will be followed up to 16 weeks monitoring lung function and inflammation through non-invasive technologies such as exhaled breath analysis (FeNO, GC-MS and EBC). A control group will be followed up to two weeks with the overall objective to indentify and evaluate the modifcations of markers of inflammation in patient under biologic treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- Severe asthma diagnosis according to the latest recommendation
- Eligible or in treatment with a biologic treatment for severe asthma
- Able to follow istructions
- Able and willing to sign the informed consent
Exclusion Criteria
- Not able to perform lung function measurements and the procedures of the study
- Acute respiratory or non respiratory infection (<4 weeks)
- Not willing to continue the study
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method evaluate the fluctuations of markers of inflammation in patients with severe asthma under biologic therapy 16 weeks
- Secondary Outcome Measures
Name Time Method evaluate whether the measurement of H2O2 could be considered as a marker of inflammation in severe asthma patients 16 weeks
Trial Locations
- Locations (1)
AOUP Policlinico Paolo Giaccone
🇮🇹Palermo, Italy
AOUP Policlinico Paolo Giaccone🇮🇹Palermo, ItalyCarmen DuranteSub InvestigatorNicola Scichilone, ProfPrincipal InvestigatorStefania Principe, PhDPrincipal InvestigatorAlida Benfante, MDSub Investigator