A Study to Compare Two Anti-HIV Drug Combinations in HIV-Infected Patients Who Have Previously Received Anti-HIV Treatment
- Conditions
- HIV Infections
- Registration Number
- NCT00004581
- Lead Sponsor
- Abbott
- Brief Summary
The purpose of this study is to compare the safety and effectiveness of 2 anti-HIV drug combinations in HIV-infected patients. Both combinations will include nevirapine (NVP), 2 nucleoside reverse transcriptase inhibitors (NRTIs), and at least 1 protease inhibitor (PI). One combination will include a new protease inhibitor, ABT-378, combined in a capsule with ritonavir (RTV).
- Detailed Description
Patients receive 1 of the following:
1. ABT-378/RTV plus NVP plus 2 NRTIs; or
2. Investigator-selected PI(s) plus NVP plus 2 NRTIs.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 300
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (88)
Clinique Medicale L'Actuele
🇨🇦Montreal, Quebec, Canada
Montreal Chest Institute
🇨🇦Montreal, Quebec, Canada
Tower ID Med Associates
🇺🇸Los Angeles, California, United States
UCLA CARE Ctr
🇺🇸Los Angeles, California, United States
Emory Univ
🇺🇸Atlanta, Georgia, United States
Philadelphia FIGHT
🇺🇸Philadelphia, Pennsylvania, United States
Johns Hopkins Hosp
🇺🇸Baltimore, Maryland, United States
Univ of Texas Southwestern Med Ctr
🇺🇸Dallas, Texas, United States
Joseph C Gathe
🇺🇸Houston, Texas, United States
Sunnybrook Health Science Ctr
🇨🇦Toronto, Ontario, Canada
San Francisco Veterans Administration Med Ctr
🇺🇸San Francisco, California, United States
Univ of Utah Med School / Clinical Trials Ctr
🇺🇸Salt Lake City, Utah, United States
Univ of Kansas School of Medicine
🇺🇸Wichita, Kansas, United States
Fundacao Zerbini Casa Da Aids
🇧🇷Sao Paulo, Brazil
Miller
🇿🇦Belford Gardens, South Africa
Stephen Hauptman
🇺🇸Philadelphia, Pennsylvania, United States
Duke Univ Med Ctr / Infectious Disease Clinic
🇺🇸Durham, North Carolina, United States
Univ Zu Koeln
🇩🇪Koeln, Germany
Division of Inf Diseases/ Indiana Univ Hosp
🇺🇸Indianapolis, Indiana, United States
Castelo
🇧🇷Sao Paulo, Brazil
Royal Brisbane Hosp
🇦🇺Herston, Australia
Clinique Medicale du Quartier Latin
🇨🇦Montreal, Quebec, Canada
EPIMED
🇩🇪Berlin, Germany
Righospitalet
🇩🇰Copenhagen, Denmark
Hvidovre Univ Hosp
🇩🇰Hvidovre, Denmark
Odense Univ Hosp
🇩🇰Odense C, Denmark
Toronto Gen Hosp
🇨🇦Toronto, Ontario, Canada
Aids Study Group Mannheim
🇩🇪Mannheim, Germany
CHU De Bicetre
🇫🇷Paris, France
Hopital Paul Brousse
🇫🇷Villejuif, France
Groupe Hospitalier Bichat-Claude Bernard
🇫🇷Paris Cedex 18, France
Hosp Virgen Del Rocio
🇪🇸Sevilla, Spain
Cyrildene
🇿🇦Johannesburg, South Africa
Hopital Gustave Dron
🇫🇷Tourcoing, France
Ctr of AIDS Diagnosis and Treatment
🇵🇱Warszawa, Poland
Ponce Univ Hosp
🇵🇷Ponce, Puerto Rico
Hosp Germans Trias I Pujol
🇪🇸Barcelona, Spain
Hosp De Mostoles
🇪🇸Madrid, Spain
Chelsea and Westminster Hosp
🇬🇧London, United Kingdom
Imperial College School of Medicine
🇬🇧London, United Kingdom
Hosp Carlos III
🇪🇸Madrid, Spain
Universitatsspital Zurich
🇨🇭Zurich, Switzerland
Brighton Gen Hosp
🇬🇧Brighton, United Kingdom
Hosp Doce De Octubre
🇪🇸Madrid, Spain
Hosp La Paz
🇪🇸Madrid, Spain
Royal Free Hosp
🇬🇧London, United Kingdom
Univ of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
Phoenix Body Positive
🇺🇸Phoenix, Arizona, United States
Pacific Oaks Med Group
🇺🇸Beverly Hills, California, United States
Orange County Ctr for Special Immunology
🇺🇸Fountain Valley, California, United States
Harbor - UCLA Med Ctr
🇺🇸Torrance, California, United States
Univ of Miami School of Medicine
🇺🇸Miami, Florida, United States
Yale Univ / AIDS Clinical Trials Unit
🇺🇸New Haven, Connecticut, United States
Infectious Disease Research Institute
🇺🇸Tampa, Florida, United States
AIDS Research Consortium of Atlanta
🇺🇸Atlanta, Georgia, United States
AIDS Research Alliance - Chicago
🇺🇸Chicago, Illinois, United States
Cook County Hosp
🇺🇸Chicago, Illinois, United States
Boston Med Ctr
🇺🇸Boston, Massachusetts, United States
Tulane Univ Med School
🇺🇸New Orleans, Louisiana, United States
Abbott Northwestern Hosp
🇺🇸Minneapolis, Minnesota, United States
Community Research Initiative of New England
🇺🇸Brookline, Massachusetts, United States
Saint Michael's Med Ctr / Dept of Infectious Diseases
🇺🇸Newark, New Jersey, United States
Beth Israel Med Ctr
🇺🇸New York, New York, United States
St Michaels Med Ctr
🇺🇸Newark, New Jersey, United States
Howard Grossman
🇺🇸New York, New York, United States
SUNY / Health Sciences Ctr at Stony Brook
🇺🇸Stony Brook, New York, United States
Cornell Clinical Trials Unit - Chelsea Clinic
🇺🇸New York, New York, United States
Oregon Health Sciences Univ
🇺🇸Portland, Oregon, United States
SUNY at Stony Brook / Div of Infectious Disease
🇺🇸Stony Brook, New York, United States
Associates in Med and Mental Health
🇺🇸Tulsa, Oklahoma, United States
Holmes Hosp / Univ of Cincinnati Med Ctr
🇺🇸Cincinnati, Ohio, United States
Oaklawn Physicians Group
🇺🇸Dallas, Texas, United States
Univ of Texas / Med Branch at Galveston
🇺🇸Galveston, Texas, United States
Hosp Do Servidor Publico Estadual De Sao Paulo
🇧🇷Sao Paulo, Brazil
The Miriam Hosp
🇺🇸Providence, Rhode Island, United States
Pulmologisches Zentrum Der Stadt Wien
🇦🇹Wien, Austria
Hosp Heliopolis
🇧🇷Sao Paulo, Brazil
Infectious Disease Physicians Inc
🇺🇸Annandale, Virginia, United States
Univ of Virginia Health Sciences Ctr
🇺🇸Charlottesville, Virginia, United States
Hosp Evandro Chagas Fioernz
🇧🇷Manguinhos RJ, Brazil
Univ of Wisconsin
🇺🇸Madison, Wisconsin, United States
Saint Paul's Hosp
🇨🇦Vancouver, British Columbia, Canada
Allgemeines Krankenhaus St Georg
🇩🇪Hamburg, Germany
Heinrich Heine Universitat
🇩🇪Dusseldorf, Germany
Klinikum Der Johann Wolfgang Goethe Universitat
🇩🇪Frankfurt, Germany
Univ of Michigan Hospitals and Health Ctrs
🇺🇸Ann Arbor, Michigan, United States
Ottawa General Hospital
🇨🇦Ottawa, Ontario, Canada
AIDS Healthcare Foundation
🇺🇸Los Angeles, California, United States