Acute Effects of Cricket Fast Bowling on Bone Turnover and Signaling Markers
Trial Snapshot
- Phase
- Not Applicable
- Status
- Enrolling By Invitation
- Sponsor
- Loughborough University
- Enrollment
- 14
- Locations
- 1
- Primary Endpoint
- Serum C-terminal telopeptide of type I collagen (CTX-I) concentration
Study Overview
Brief Summary
The goal of this study is to investigate the acute effects of cricket fast bowling on the bone turnover and signaling markers in healthy young males.
The main question aims to answer:
• Does a single bout acute fast bowling change serum C-terminal telopeptide of type I collagen (CTX-I) and other bone turnover and signaling markers levels?
Participants complete both the bowling and control trials, with a minimum washout period of one week between trials. During each trial, blood samples are collected at three time points: pre-, immediately post, and 2-hour post bowling/rest.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 30 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy male
- •Aged 18 - 30
- •Cricket fast bowlers (a ball speed of ~100kmh) playing for a university team or above, such as British Universities and Colleges Sport (BUCS) or University Centre of Cricketing Excellence (UCCE)
- •Injury free for the last 3 months
Exclusion Criteria
- •Diagnosed with any disease or use of any medication that affects bone turnover
- •Fracture experienced within the previous year/season
Arms & Interventions
Arm Bowling + Control
Participants first perform the bowling trial, followed by the control trial, with a minimum interval of one week between the two trials.
Intervention: Exercise (Behavioral)
Arm Control + Bowling
Participants first perform the control trial, followed by the bowling trial, with a minimum interval of one week between the two trials.
Intervention: Exercise (Behavioral)
Outcomes
Primary Outcomes
Serum C-terminal telopeptide of type I collagen (CTX-I) concentration
Time Frame: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum CTX-I concentration is measured using electrochemiluminescence immunoassay (ECLIA) and reported in nanograms per milliliter (ng/mL).
Secondary Outcomes
- Serum N-terminal propeptide of type I collagen (PINP) concentration(Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.)
- Serum parathyroid hormone (PTH) concentration(Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.)
- Serum sclerostin concentration(Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.)
- Serum dickkopf Wnt signaling pathway inhibitor 1 (DKK1) concentration(Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.)
- Serum osteoprotegerin (OPG) concentration(Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.)
- Serum irisin concentration(Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.)
- Bowling speed(Bowling speed is measured during the bowling trial.)
Investigators
Katherine Brooke-Wavell
Professor
Loughborough University