Primairy prevention of atopic disease by perinatal administration of probiotics.
Recruiting
- Conditions
- A randomised double-blind intervention study in pregnant mothers from atopic families and in their newborns.
- Registration Number
- NL-OMON26444
- Lead Sponsor
- Wilhelmina Children's Hospital, PO box 85090, 3508 AB Utrecht, The Netherlands.
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
Pregnant mothers were included if either they themselves or their husband plus a sibling suffered from present or past atopic disease.
Exclusion Criteria
1. Maternal use of immunomodulatory drugs during pregnancy;
2. The use of probiotics.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence and severity of atopic disease at the age of 2 years.
- Secondary Outcome Measures
Name Time Method 1. SCORAD;<br /><br>2. Lung function;<br /><br>3. Serum IgE (Total and specific);<br /><br>4. Cytokines produced by peripheral blood derived mononuclear cells;<br /><br>5. Bacterial content of stools during the first weeks of life.