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A 5-year Longitudinal Observational Study of Patients Undergoing Therapy for Inflammatory Bowel Disease

Recruiting
Conditions
Inflammatory Bowel Diseases
Crohn's Disease
Ulcerative Colitis
Indeterminate Colitis
Registration Number
NCT03251118
Lead Sponsor
Target PharmaSolutions, Inc.
Brief Summary

TARGET-IBD is a 5-year, longitudinal, observational study of adult and pediatric patients (age 2 and above) being managed for Inflammatory Bowel Disease (IBD) in usual clinical practice. TARGET-IBD will create a research registry of patients with IBD within academic and community real-world practices in order to assess the safety and effectiveness of current and future therapies.

Detailed Description

Not available

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
15000
Inclusion Criteria
  1. Adults and children (age 2 or older) with a diagnosis of Crohn's disease (CD), Ulcerative colitis (UC), or Indeterminate colitis (IBDU) having been prescribed any IBD treatment (initial or subsequent) outside of a clinical trial.
  2. Have plans for future visits at the site for continued management of IBD.
Exclusion Criteria
  1. Inability to provide written informed consent/assent.
  2. Being enrolled in any interventional study or trial for IBD treatment. Note: Patient may be enrolled in other registries or studies where IBD treatment outcomes are observed and/or reported (such as center-based registries).
  3. Prior total abdominal colectomy for UC or IBDU.

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Natural history of Inflammatory Bowel Disease: Treatment responseUp to 5 years
Natural history of Inflammatory Bowel Disease: Participant demographicsUp to 5 years
Natural history of Inflammatory Bowel Disease: Treatment useUp to 5 years
Natural history of Inflammatory Bowel Disease: Characteristics of IBDUp to 5 years
Natural history of Inflammatory Bowel Disease: Disease progressionUp to 5 years
Secondary Outcome Measures
NameTimeMethod
Self-reported patient health measures: EQ-5DEvery 3 months for 5 years
Self-reported patient health measures: PRO-2 for Crohn's DiseaseEvery 3 months for 5 years
Reasons for treatment discontinuationUp to 5 years
Self-reported patient health measures: PRO-2 for Ulcerative colitisEvery 3 months for 5 years
Self-reported patient health measures: Manitoba IBD Index (MIBDI)Every 3 months for 5 years
Timepoint of endoscopic responseUp to 5 years
Self-reported patient health measures: 2-question Adherence MeasureEvery 3 months for 5 years
Timepoint of endoscopic remissionUp to 5 years
Endoscopic measures of mucosal healingUp to 5 years
Adverse event frequency and severityEvery 3 months for 5 years
Timepoint of clinical responseEvery 3 months for 5 years
Self-reported patient health measures: Pediatric Ulcerative colitis Activity Index (PUCAI)Every 3 months for 5 years

Trial Locations

Locations (37)

Om Research

🇺🇸

Lancaster, California, United States

FACEY Medical Foundation

🇺🇸

Mission Hills, California, United States

University of California - Davis

🇺🇸

Sacramento, California, United States

Stanford University

🇺🇸

Stanford, California, United States

University of Colorado Denver

🇺🇸

Aurora, Colorado, United States

Gastro Florida

🇺🇸

Clearwater, Florida, United States

University of Florida Health Jacksonville-Gastroenterology

🇺🇸

Jacksonville, Florida, United States

Advanced Gastroenterology Associates, LLC

🇺🇸

Palm Harbor, Florida, United States

Atlanta Gastro

🇺🇸

Atlanta, Georgia, United States

The University of Chicago Medical Center

🇺🇸

Chicago, Illinois, United States

Indianapolis Gastroenterology Research Foundation

🇺🇸

Indianapolis, Indiana, United States

University of Iowa Hospitals and Clinics

🇺🇸

Iowa City, Iowa, United States

Gastroenterology Associates

🇺🇸

Baton Rouge, Louisiana, United States

Louisiana Research Center, LLC

🇺🇸

Shreveport, Louisiana, United States

University of Michigan Medical Center

🇺🇸

Ann Arbor, Michigan, United States

University of Minnesota

🇺🇸

Minneapolis, Minnesota, United States

Saint Louis University

🇺🇸

Saint Louis, Missouri, United States

University of Nebraska Medical Center

🇺🇸

Omaha, Nebraska, United States

Dartmouth-Hitchcock Medical Center

🇺🇸

Lebanon, New Hampshire, United States

Rutgers, Robert Wood Johnson Medical School

🇺🇸

New Brunswick, New Jersey, United States

The Children's Hospital at Montefiore

🇺🇸

Bronx, New York, United States

NYU Langone Health

🇺🇸

New York, New York, United States

Mount Sinai, Icahn School of Medicine

🇺🇸

New York, New York, United States

Premier Medical Group of the Hudson Valley

🇺🇸

Poughkeepsie, New York, United States

Cary Gastroenterology Associates

🇺🇸

Cary, North Carolina, United States

University of North Carolina

🇺🇸

Chapel Hill, North Carolina, United States

Carolinas Healthcare System-Center for Digestive Health

🇺🇸

Charlotte, North Carolina, United States

Digestive Health Specialists, PA

🇺🇸

Winston-Salem, North Carolina, United States

Cleveland Clinic/DIgestive Disease and Surgery Institute

🇺🇸

Cleveland, Ohio, United States

The Ohio State University Wexner Medical Center

🇺🇸

Columbus, Ohio, United States

University of Pennsylvania

🇺🇸

Philadelphia, Pennsylvania, United States

Vanderbilt University Medical Center

🇺🇸

Nashville, Tennessee, United States

UT Southwestern

🇺🇸

Dallas, Texas, United States

Baylor College of Medicine

🇺🇸

Houston, Texas, United States

Swedish Medical Center

🇺🇸

Seattle, Washington, United States

MultiCare Institute for Research and Innovation

🇺🇸

Tacoma, Washington, United States

University of Wisconsin Hospital & Clinics

🇺🇸

Madison, Wisconsin, United States

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