Association Between Plasma D Dimer in Adult CAP and Severity of Inflammatory Response and Survival

Recruiting

• Conditions: D-dimer

• Registration Number: NCT07199530
• Lead Sponsor: Ain Shams University

Brief Summary

This is an observational study aiming to investigate the association between elevated plasma D-dimer levels and the inflammatory response, as well as the impact on survival in adult patients with community acquired pneumonia.

the study participants will be subjected to sampling for D dimer and calculation of CURB 65 score. this aims to find the relation between them

Detailed Description

Community-acquired pneumonia (CAP) is a common and potentially life-threatening infection that affects millions of individuals worldwide each year.

D-dimer is a fibrin degradation product that is elevated in many conditions associated with inflammation and coagulation activation, including pneumonia.

This is an observational study including a minimum of 50 patients with CAP

Patients who will be admitted at Chest department, or coming to the outpatient clinic Ain-Shams University Hospitals with CAP and have the following inclusions:

1. age ≥18 years

2. diagnosis of CAP based on clinical symptoms, laboratory findings, and radiological evidence.

3. Did not have any clinical or radiological signs suggesting Covid pneumonia Exclusion criteria Patients with a history of coagulation disorders, cancer, or other chronic diseases, or refusal to participate.

All patients will be subjected to the following: -

1. Full medical history, demographics

2. Thorough clinical examination.

3. laboratory values (including white blood cell count, CRP, and D-dimer), With pre and post sample known precautions (8).

4. Radiological findings (CXR).

5. Severity of illness (based on the CURB-65 score).

Study Timeline

• Status Verified: 2025-06
• Study Start: 2025-06-23
• Study First Submitted: 2025-09-22
• Study First Submitted QC: 2025-09-22
• Last Update Submitted: 2025-09-22
• Study First Posted: 2025-09-30
• Last Update Posted: 2025-09-30
• Primary Completion: 2025-12
• Study Completion: 2026-02-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Patients who will be admitted at Chest department, or coming to the outpatient clinic Ain-Shams University Hospitals with CAP and have the following inculsions:

  1. age ≥18 years
  2. diagnosis of CAP based on clinical symptoms, laboratory findings, and radiological evidence.

Exclusion Criteria

• Patients with a history of coagulation disorders, cancer, or other chronic diseases, or refusal to participate.
• patients who have any clinical or radiological signs suggesting Covid pneumonia.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
find the association between plasma D dimer level and severity of CAP	in 6 months

Trial Locations

Locations (1)

Ain Shams University hospitals; 🇪🇬 Cairo, Egypt