Association of Serum 25-hydroxyvitamin D Levels and Outcomes in Children With Bacterial Meningitis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 主要终点
- vitamin d level change
研究概览
简要总结
The purpose of this study is to determine whether deficiency of Vitamin D has association with outcomes of children with bacterial meningitis.
详细描述
Vitamin D deficiency has been proved in serious diseases patients, including patients in shock, however, few study have been done about association between deficiency of Vitamin D and outcomes of children with bacterial meningitis.
in our study, we will observe incidence of complication and severity of complication between patients who have different Vitamin D status.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Month 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Probable bacterial meningitis patients: Clinical manifestation (Any person with sudden onset of fever (> 38.5 °C rectal or 38.0 °C axillary) and one of the following signs: neck stiffness, altered consciousness or other meningeal sign) with cerebrospinal fluid examination showing at least one of the following:
- •A. turbid appearance; B.leukocytosis (> 100 cells/mm3); C.leukocytosis (10-100 cells/ mm3) AND either an elevated protein (> 100 mg/dl) or decreased glucose (< 40 mg/dl)
- •Confirmed bacterial meningitis patients: A case that is laboratory-confirmed by growing (i.e. culturing) or identifying (i.e. by Gram stain or antigen detection methods) a bacterial pathogen (Hib, pneumococcus or meningococcus) in the cerebrospinal fluid or from the blood in a child with a clinical syndrome consistent with bacterial meningitis
排除标准
- •Congenital immunodeficiency patients
- •HIV patients
- •Patients with corticosteroid treatment for long time
- •Patients with disorders in adrenal gland and pituitary gland and hypothalamus
- •Patients with tuberculosis
结局指标
主要结局
vitamin d level change
时间窗: change in serum vitamin d level from baseline to 28 days after initial hospitalization
Serum vitamin d level will be detected in the first day of hospitalization and twenty-eighth day of hospitalization, no vitamin d supplementation during this time
次要结局
- Clinical assessment of disease severity with Glasgow score(28 day)
- Clinical assessment of disease severity with cerebrospinal fluid examination(28 day)
- Assessment of complications(28 day)
- Clinical assessment of disease severity with pediatric critical illness score(28 day)
研究者
Gang Liu
director, chief physician, professor
Beijing Children's Hospital