Association Between Serum 25-hydroxyvitamin D Levels and Glycated Haemoglobin in Diabetic Patients With Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 主要终点
- HbA1c levels
研究概览
简要总结
The purpose of this study is to determine the association between serum 25-hydroxyvitamin D and HbA1c levels in diabetic patients with chronic kidney disease. The investigators hypothesized that serum 25-hydroxyvitamin D levels were negatively correlated with HbA1c levels.
详细描述
This was a cross sectional study using consecutive sampling methodology for participant recruitment. It was carried out at the specialized diabetic, renal, and general outpatient clinics in the University of Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia.
Serum 25(OH)D levels were determined by using direct chemiluminesent immunoassay (ADVIA Centaur XP; Siemens Healthcare Diagnostics, Tarrytown, New York, USA). Serum HbA1c levels were determined using high-pressure liquid chromatography (Variant™ II Turbo; Bio-Rad, Hercules, California, USA).
Data collected will be analyzed using Statistical Package for Social Sciences SPSS version 23.0 for Windows, version 23.0 (IBM Corp., Armonk, New York, USA).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •eGFR 15-59 ml/min/1.73m2
- •age ≥ 18 years old
- •able to provide informed consent
排除标准
- •active infections
- •autoimmune diseases
- •malignancies
- •on immunosuppressive therapy
- •on vitamin D supplements
结局指标
主要结局
HbA1c levels
时间窗: Within 2 weeks from enrolment
The unit of measure was percentage (using NGSP standarization).
25-hydroxyvitamin D levels
时间窗: Within 2 weeks from enrolment
The unit of measure was nmol/L. The detection limit of the device was \<10 nmol/L. A mean value of 5 nmol/L were taken for results reported as \<10nmol/L.
次要结局
未报告次要终点
研究者
Ng Yong Muh
Dr
University of Malaya