Serum 25-hydroxyvitamin D, Vascular Functioning, and Insulin Sensitivity in Adolescent Girls [The DIVA Study (Vitamin D, Insulin, and Vascular Associations)] (Pediatric Physician Training in Translational Research)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- Insulin Sensitivity
研究概览
简要总结
The overall objectives of this study are to examine the relationships between circulating vitamin D, insulin sensitivity, and multiple indices of vascular function and to examine whether vitamin D deficiency in AA is responsible for ethnic differences in insulin sensitivity and hypertension in AA and EA, as well as mechanisms underlying the association between insulin resistance and blood pressure. We hypothesize that 1) serum 25(OH)D is associated with insulin sensitivity and vascular functioning, independent of adiposity, 2) lower insulin sensitivity and vascular functioning in AA relative to EA is due to lower circulating 25(OH)D in AA, and 3) the relationship between insulin resistance and vascular dysfunction is mediated by 25(OH)D.
Acronyms: African American (AA), European American (EA), Serum 25-hydroxy vitamin D (25()H)D, Body mass index (BMI), Alabama (AL).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 14 Years 至 18 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •African American or Caucasian ethnicity
- •Ages 14-18 yrs
排除标准
- •BMI-for age and -sex higher than 95th centile on the Centers for Disease Control and Prevention Growth Charts
- •Use of medication(s) known to influence body composition, vascular function, or glucose metabolism
- •Pregnancy
- •Diabetes or any chronic diseases
结局指标
主要结局
Insulin Sensitivity
时间窗: Cross sectional study: at the first study visit
次要结局
- Vascular Function(Cross sectional study: at the second study visit, within 2 weeks of first study visit)
研究者
Ambika Ashraf, M.D.
Associate Professor, Pediatrics
University of Alabama at Birmingham