Comparison of the analgesic effect of three analgesics before surgery in pain after mandibular wisdom tooth surgery

Phase 2

Recruiting

Conditions: postoperative pain.
Pain, not elsewhere classified

Registration Number: IRCT20221207056746N1

Lead Sponsor: Mazandaran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 120

Inclusion Criteria

Healthy patients (ASA class I)
Candidates of prophylactic removal of mandibular third molar,full or partial bony impaction confirmed by panoramic X-ray
Requiring soft tissue flap, bone manipulation and bone removal
No medication consumption in the past 21 days
The presence of the first and second molars
Good oral hygiene
Absence of pericoronitis or inflammation signs
Absence of local or systemic infection

Exclusion Criteria

Smokers
Pregnant or breastfeeding women or women of child bearing potential not using adequate contraception
Allergy or hypersensitivity to study treatments, rescue medication (rm) or any other nsaids, opioids and acetyl salicylic acid
History of NSAID-sensitive asthma
History of or the suspicion of drug or alcohol abuse
Apical radiolucent image in target tooth
Consmuption of central nervous system depressants
Pre-existing pain and acute inflammation
Inability to understand or perform the study procedure
Psychosis
Consumption of caffeine-containing beverages, chocolate, or alcohol within 4 hours prior to surgery
Oral contraception use
Being in the menstrual period
Any contraindication of cox-2 inhibitors use

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative pain intensity. Timepoint: 4hours & 7 hours postsurgery,the first day and the third day after surgery. Method of measurement: Visual Analogue Scale.;The time of first analgesic intake. Timepoint: one week after surgery. Method of measurement: Referring to document.;The number of patients who needed analgesics (vas=4). Timepoint: One week after surgery. Method of measurement: Referring to patients' documents.;The total number of analgesics used. Timepoint: One week after surgery. Method of measurement: Referring to patients' documents.

Secondary Outcome Measures