Measurement of Lipogenic Flux by Deuterium Resolved Mass Spectrometry Via Non-invasive Breath Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 5
- 试验地点
- 2
- 主要终点
- Variation of signal intensity of deuterated exhaled metabolites across the approximately lasting 4.5 hours trial
研究概览
简要总结
This proof of concept- study is to measure de novo lipogenesis (DNL) non-invasively in exhaled breath in overnight-fasted humans by triggering feeding response by deuterium resolved mass spectrometry.
详细描述
The study objective is to measure the DNL by ingestion of a single oral dose of 70% 2H2O at 2 g/kg body-water. The subjects will consume a Yoghurt consisting of 300g of 'Excellence Joghurt Nature gezuckert' which contains 410 Kcal, 28g fat, 34g carbohydrates and 9g protein. The exhaled air of the subjects will be measured several times per hour to analyse de novo lipogenesis (DNL) non-invasive by deuterium resolved mass spectrometry.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adult volunteers
- •English speaking, or good knowledge of the English language
- •Able to understand the study
- •Able to give informed consent
排除标准
- •Current pregnancy
结局指标
主要结局
Variation of signal intensity of deuterated exhaled metabolites across the approximately lasting 4.5 hours trial
时间窗: approximately 4.5 hours
Variation of signal intensity of deuterated exhaled metabolites across the approximately lasting 4.5 hours trial
次要结局
未报告次要终点