A Comparison Between Sonoguided Injection Corticosteroid and Hyaluronic Acid Injection in Treatment of Trigger Finger

Not Applicable

Completed

• Conditions: Trigger Finger
• Interventions: Drug: triamcinolone acetonide; Drug: Hyaluronic Acid

• Registration Number: NCT01950793
• Lead Sponsor: Taipei Veterans General Hospital, Taiwan

Brief Summary

The study is to compare the effect between steroid injection and Hyaluronic acid in treatment trigger finger. Using sonoguided injection technique achieves more accurate injection location and therapeutic effect. We hypothesize hyaluronic acid has both lubricant and anti-inflammation effect in treatment of trigger finger, and can provide better outcome and lower adverse effect than steroid injection.

Detailed Description

This is a prospective, randomized, double-blinded controlled study. Patients with the diagnosis of trigger finger will be recruited and enrolled from Taipei Veteran General Hospital PM\&R outpatient clinic. Subjects will be randomized into two groups; hyaluronic acid and triamcinolone acetonide injections, both via ultrasound-guided with one injection only.We hypothesize that through the anti-inflammatory property of the hyaluronate acid, the treatment effects will be as effective as the traditionally used steroid injections with equal or even lower recurrence rate for treatment of trigger finger. We expect that injections of hyaluronate into tendon sheath could become a new treatment option for trigger finger.

Study Timeline

• Study Start: 2012-11
• Study First Submitted: 2013-09-23
• Study First Submitted QC: 2013-09-24
• Study First Posted: 2013-09-25
• Primary Completion: 2014-05
• Study Completion: 2014-08
• Status Verified: 2014-11
• Last Update Submitted: 2014-11-02
• Last Update Posted: 2014-11-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• patients with trigger digits and patients
• without previous treatment of the trigger digit

Exclusion Criteria

• patients with prior treatment of the trigger digit (eg, splinting, injection, or therapy),
• patients less than
• 20 years old,
• patients with allergy or contraindication to hyaluronic acid,
• patients with trigger digits due to rheumatoid arthritis,
• and patients with infection at the site of injection.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
steroid	triamcinolone acetonide	used ultrasound-guided inject 1c.c triamcinolone acetonide 10mg/mL (Shincort®, YSP, Taiwan)into the sheath of the flexor tendons, penetrated to the A1 pulley. One injection only
Hyaluronic acid	Hyaluronic Acid	used ultrasound-guided inject 1c.c Hyaluronic acid (Artz®, Seikagaku, Japan)into the sheath of the flexor tendons, penetrated to the A1 pulley. One injection only

Primary Outcome Measures

Name	Time	Method
Quinnell classification	Pre-injection; 3-weeks and 3-months post-injections	he Quinnell system grades trigger fingers as: 0 - normal movement; 1. - uneven movement; 2. - locking can be corrected with active motion; 3. - locking corrected with passive motion; 4. - unable to correct deformity

Secondary Outcome Measures

Name	Time	Method
hand functional evaluation	Pre-injection; 3-weeks and 3-months post-injections	using the Michigan Hand Outcome Questionnaire (MHQ)
visual analog scale	Pre-injection; 3-weeks and 3-months post-injections
total active motion (TAM)	Pre-injection; 3-weeks and 3-months post-injections	Defi ned as the total ROM achieved when all three joints-metacarpophalangeal (MCP), proximal interphalangeal (PIP) and distal interphalangeal (DIP) of a digit are actively fl exed or extended simultaneously, minus any extension defi cit at any of the three joints
grip strength	Pre-injection; 3-weeks and 3-months post-injections	dynamometer strength test (JAMAR grip)

Trial Locations

Locations (1)

Taipei Veterans General Hospital; 🇨🇳 Taipei, Taiwan