Influenza Vaccination Among the Elderly Individuals
- Conditions
- Influenza
- Registration Number
- NCT02362919
- Lead Sponsor
- Helmholtz Centre for Infection Research
- Brief Summary
The aims of the study are to a) identify individuals with a poor response to influenza vaccination and b) identify factors associated with a poor response to influenza vaccination.
- Detailed Description
This is a population-based prospective cohort study. Potential participants, males and females between 65 and 80 years of age, were selected randomly through the resident registration office in Hannover city, Germany and invited with a personalized letter to participate in the study.
Initially, a blood sample (40 ml) will be drawn from each participant (day 0). Furthermore, participants will be vaccinated against influenza with FLUAD 2014/2015. FLUAD is a trivalent, surface antigen, inactivated influenza virus vaccine adjuvanted with MF59C.1. Additional five blood samples will be collected during the study period of four months (at days 3, 7, 21, 70 and 130). Information about current and past infections, chronic diseases and basic sociodemographic data will be collected through a self-administered questionnaire.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 200
- Individuals between 65 and 80 years of age
- Individuals with a known hypersensitivity to any of the excipients and to eggs, chicken Protein, kanamycin and neomycin sulphate, formaldehyde, and cetyltrimethylammonium bromide
- Individuals, who have an acute infection during the visit at the study Center
- Individuals with cognitive impairment
- Individuals already vaccinated with influenza vaccination in the influenza season 2014/15
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serological evidence of vaccine response to influenza vaccination 4 months
- Secondary Outcome Measures
Name Time Method