Modelling the effect of fibrates on lipoproteins in patients with dyslipidemia

Recruiting

Conditions: HYPERTRIGLYCERIDMIE
E78
Disorders of lipoprotein metabolism and other lipidaemias

Registration Number: DRKS00017404

Lead Sponsor: niversitätsklinikum Freiburg Institut für klinische Chemie und Laboratoriumsmedizin

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 30

Inclusion Criteria

• Age = 18
• written consent
• Serum TG > 600 mg/dl

Exclusion Criteria

1. serious liver dysfunction (Child-Pugh C)
2. serious kidney dysfunction, with GFR < 30 ml/min/1,73 m²
3. TSH not normal
4. not-controlled arterial hypertension: systolic RR > 160 mmHg or diastolic bp > 105 mmHg.
5. alcoholabusus, or abusus of other drugs (but nicotine)
6. Blood-donation within the last 6 weeks prior to the first blood withdrawal
7. Patients with serious acute diseases
8. HbA1c > 8.0%
9. Other serious internistic diseases, associated to the lipid-metabolism
10. hypersensivity to fibrats
11. pregnancy, planned pregnancy or lactation

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Estimation of the lipidfluxes (per Cholesterol ester-Transferprotein (CETP), Lecithin-Cholesterol-Acyltransferase (LCAT) and hepatic lipasis (HL)) in low density lipoproteins (LDL) and high density lipoproteins (HDL). This is done with a mathematical model, based on measurements of triglyzerides, unesterified cholesterol, and cholesterol estern in very low density lipoproteins (VLDL) , intermediate density lipoproteins (IDL), LDL and HDL, as well as Apolipoprotein B-100 (ApoB) in VLDL, IDL, LDL and Apolipoprotein A1 (ApoA1) in HDL.

Secondary Outcome Measures

Name	Time	Method
- Concentration of phospholipids in VLDL, IDL, LDL and HDL and concentration of triglyzerides, cholesterpl, Cholesterpl ester, phospholipids in the subfractions of LDL und HDL <br>- ApoB in VLDL, IDL, LDL-1 to LDL-6 and ApoAI in HDL subfractionen 2a, 2b und HDL-3 <br>- HDL-functionality<br>- concentration and distribution of other apolipoproteins in the lipoprotein-subfractions<br>- Activities of the enzyms: phospholipid-transfer-protein (PLTP), lipoprotein-associated phospholipase A2 (Lp-PLA2) <br>