Bleeding Prediction in Patients Undergoing Cardiac Surgery Using Whole Blood Impedance Aggregometry and Rotational Thromboelastometry
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 148
- 试验地点
- 1
- 主要终点
- Chest tube output in first 24 hours
研究概览
简要总结
Use of whole blood impedance aggregometry and rotational thromboelastometry can reveal useful data about platelet function and viscoelastic properties of blood clot in patients undergoing cardiac surgery.
The purpose of this study is to clarify whether it is possible to predict patients on excessive risk of perioperative bleeding using whole blood impedance aggregometry and rotational thromoelastometry.
Antiplatelet therapy is the cornerstone in treatment of patients with coronary artery disease. Another research goal is to determine the degree of response to antiplatelet therapy before and after surgery and to investigate whether patients by level of response to antiplatelet therapy before surgery have a higher risk of perioperative bleeding.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •> 18 years old
- •Elective cardiac surgery patients
- •Coronary artery disease
- •Aortic valve disease
- •Mitral valve disease
- •Ascendent aorta aneurysm
- •Combine coronary and valve disease
- •Cardiac surgery procedures using cardiopulmonary bypass
排除标准
- •Missing consent
- •Patients with emergent cardiac surgical procedures
- •Patients on antiplatelet therapy other than aspirin or clopidogrel
- •Patients with inaccurate antiplatelet therapy administration documentation
- •Missing data
- •Off-pump procedures
- •Patients younger than 18 years old
- •Patients with severe mental disorders
- •Intrinsic coagulopathy
结局指标
主要结局
Chest tube output in first 24 hours
时间窗: 24 hours after surgical procedure
次要结局
- Allogenic blood products transfusion(7 days after surgery including the day of surgery)
研究者
Petricevic Mate
Mate Petricevic M.D. , Ph.D.
University of Zagreb