Steroids And Laser Trabeculoplasty (SALT) Trial: Effect of Anti-Inflammatory Treatment on the Efficacy of SLT
Overview
- Phase
- Phase 4
- Intervention
- Artificial Tears
- Conditions
- Glaucoma
- Sponsor
- Stanford University
- Enrollment
- 97
- Locations
- 2
- Primary Endpoint
- Intraocular Pressure (IOP) Change
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The purpose of this study is to determine whether the choice of post-operative eye drop administered after selective laser trabeculoplasty (SLT) for glaucoma affects the efficacy in lowering intraocular pressure (IOP).
Detailed Description
SLT is used to lower intraocular pressure in glaucoma, but it is not know whether the choice of eyedrops administered in the post-operative period affects SLT efficacy. Practitioners commonly use steroid drops, non-steroidal anti-inflammatory drops, or no drops at all. This is a randomized, single-center, prospective, masked clinical trial to determine whether the choice of eyedrop affects efficacy of SLT in glaucoma patients.
Investigators
Jeffrey L Goldberg
Professor of Ophthalmology
Stanford University
Eligibility Criteria
Inclusion Criteria
- •clinical diagnosis of glaucoma
- •clinician has determined that SLT laser is indicated
- •IOP currently \>18 and was ever \>21 in the past (e.g. prior to treatment)
Exclusion Criteria
- •prior history of uveitis
- •prior glaucoma surgery including glaucoma laser surgery
- •pregnant or 3 months post-partum
Arms & Interventions
Artificial Tears
Topical artificial tears dosed 4 times per day for 4 days in treated eye after laser trabeculoplasty.
Intervention: Artificial Tears
Non-steroidal anti-inflammatory
Topical ketorolac 0.5% dosed 4 times per day for 4 days in treated eye after laser trabeculoplasty.
Intervention: Ketorolac
Steroid
Topical prednisolone 1% dosed 4 times per day for 4 days in treated eye after laser trabeculoplasty.
Intervention: Prednisolone 1%
Outcomes
Primary Outcomes
Intraocular Pressure (IOP) Change
Time Frame: Baseline to Week 12
IOP will be measured before and at 6 and 12 weeks after intervention using Goldman tonometry.
Secondary Outcomes
- Intraocular Inflammation(Up to week 12)