Prospective Study on the Risks of Symptomatic Dengue on Pregnancy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Dengue
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
- Enrollment
- 336
- Locations
- 1
- Primary Endpoint
- Evaluate the difference in the proportion of intrauterine growth retardation (IUGR) between the Case group and the Control group
- Last Updated
- 4 years ago
Overview
Brief Summary
Dengue fever is the most common arbovirus worldwide (390 million people infected per year) and is a global public health problem. This public health problem is also becoming European due to its rapid expansion over the past decade with an increase in cases of 400% and the appearance of the first indigenous cases of dengue in Europe. Studies on the consequences of dengue fever on pregnancy find contradictory results. In fact, most of these studies are observational studies describing the risk of dengue fever for pregnancy, without comparison with a control group or comparing the different pregnancy morbidities to those found during pregnancy in the general population. Other research is retrospective case-control studies with major biases in the definitions of obstetric complications, which makes the results questionable.
The study therefore proposes to carry out a prospective case-control study with rigorous matching criteria, strict definitions of cases, controls and obstetric complications.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Evaluate the difference in the proportion of intrauterine growth retardation (IUGR) between the Case group and the Control group
Time Frame: at childbirth
Birth weight \<3rd percentile according to Sentinel Network Perinatal Database : AUDIPOG
Secondary Outcomes
- Evaluate the difference in the proportion of preeclampsia between the case group and the control group(at childbirth)
- Evaluate the difference in the proportion of small weight for gestational age between the case group and the control group between the case group and the control group(at childbirth)
- Evaluate the difference in the proportion of prematurity between the case group and the control group(at childbirth)
- Evaluate the difference in the proportion of late miscarriage between the case group and the control group(at childbirth)
- Evaluate the difference in the proportion of fetal death in utero between the case group and the control group(at childbirth)
- Evaluate the difference in the proportion of bleeding from delivery between the case group and the control group between the case group and the control group(at childbirth)