DRKS00004646已完成不适用
ong-term sequelae after septic multi-organ failure - a pilot study on immunological, neuroendocrine and metabolic changes in post-acute-care hospital
Integriertes Forschungs- und BehandlungszentrumCenter of Sepsis Control and CarePaul-Martini-Forschergruppe ”Clinical Septomics”0 个研究点目标入组 24 人开始时间: 2013年1月16日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 24
研究概览
简要总结
The present findings reveal that CCI sepsis patients feature signs of immune suppression but that their T cells exhibit a primed, rather than a suppressed, phenotype in their TCR response, arguing against a generalized T cell paralysis as a major cause of protracted immune suppression from sepsis.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 55 Years 至 80 Years（—）
- 性别
- Male
入选标准
- •1. Male patients, age 55-80 years
- •2. State after SIRS / sepsis with multiple organ failure in the pre-treating acute hospital
- •3. Presence of critical illness polyneuropathy and myopathy (CIPNP and CIMP)
- •4. Chronic critical illness with 2-organ failure:
- •- Prolonged mechanical ventilation > 3 weeks and < 12 weeks
- •- state after acute renal failure and currently running renal replacement therapy
排除标准
- •1. Previous chemotherapy or radiation therapy
- •2. C-reactive protein mg> 140 / L
- •3. Chronic immunosuppression
- •4. Treatment with Prednisolone within the last 8 days before taking blood samples
- •5. Current septic inflammation
- •6. Chronic renal failure with ambulant dialysis
- •7. Current therapy with vasopressors
- •8. Acute Lung Injury (ALI): FiO2> 30%
- •9. Traumatic Brain Injury
- •10. Intracerebral hemorrhage / stroke within the last 12 weeks
研究者
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