DRKS00004646
已完成
不适用
ong-term sequelae after septic multi-organ failure - a pilot study on immunological, neuroendocrine and metabolic changes in post-acute-care hospital
Integriertes Forschungs- und BehandlungszentrumCenter of Sepsis Control and CarePaul-Martini-Forschergruppe ”Clinical Septomics”0 个研究点目标入组 24 人2013年1月16日
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Severe SepsisSeptic shockChronic critical illnessImmunosuppressionHealthy volunteer
- 发起方
- Integriertes Forschungs- und BehandlungszentrumCenter of Sepsis Control and CarePaul-Martini-Forschergruppe ”Clinical Septomics”
- 入组人数
- 24
- 状态
- 已完成
- 最后更新
- 去年
概览
简要总结
The present findings reveal that CCI sepsis patients feature signs of immune suppression but that their T cells exhibit a primed, rather than a suppressed, phenotype in their TCR response, arguing against a generalized T cell paralysis as a major cause of protracted immune suppression from sepsis.
研究者
入排标准
入选标准
- •1\. Male patients, age 55\-80 years
- •2\. State after SIRS / sepsis with multiple organ failure in the pre\-treating acute hospital
- •3\. Presence of critical illness polyneuropathy and myopathy (CIPNP and CIMP)
- •4\. Chronic critical illness with 2\-organ failure:
- •\- Prolonged mechanical ventilation \> 3 weeks and \< 12 weeks
- •\- state after acute renal failure and currently running renal replacement therapy
排除标准
- •1\. Previous chemotherapy or radiation therapy
- •2\. C\-reactive protein mg\> 140 / L
- •3\. Chronic immunosuppression
- •4\. Treatment with Prednisolone within the last 8 days before taking blood samples
- •5\. Current septic inflammation
- •6\. Chronic renal failure with ambulant dialysis
- •7\. Current therapy with vasopressors
- •8\. Acute Lung Injury (ALI): FiO2\> 30%
- •9\. Traumatic Brain Injury
- •10\. Intracerebral hemorrhage / stroke within the last 12 weeks
结局指标
主要结局
未指定
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