DRKS00003579
Recruiting
Not Applicable
ong-term Immunological Sequelae in Sepsis-Survivors - LOSS
niversitätsklinikum JenaFriedrich-Schiller-UniversitätCenter for Sepsis Control and Care (CSCC)0 sites59 target enrollmentFebruary 29, 2012
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- SepsisSevere SepsisSeptic Shock
- Sponsor
- niversitätsklinikum JenaFriedrich-Schiller-UniversitätCenter for Sepsis Control and Care (CSCC)
- Enrollment
- 59
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Key Inclusion Criteria Patient:
- •1\.Sepsis, Severe sepsis, or septic shock based on the definitions by the ACCP/SCCM Consensus Conference:
- •\- Sepsis: SIRS with documented infection
- •\-\-\>SIRS: presence of at least two criteria:
- •1\) body temperature \<36°C or \>38°C),
- •2\) tachycardia (\>90 beats/min),
- •3\) tachypnea (\>20 breaths/min or PaCO2\< 4\.3kPa \[32 mmHg], or need for mechanical ventilation),
- •4\) white blood count \<4000 cells/µl or \>12,000 cells/µl.
- •\-\-\> Infection: defined by the International Sepsis Forum Consensus Conference on Definitions of Infection in the Intensive Care Unit.
- •\-Severe sepsis: sepsis with at least one manifestation of inadequate organ perfusion or function:
Exclusion Criteria
- •Key Exclusion Criteria Patient:
- •1\. Systemic autoimmune disease, malignant hemopathy, HIV infection, transplantation, immunosuppressive medication (corticosteroids with \>10mg prednisolone equivalent/day)
- •2\. Chemo\- or radiotherapy due to malignancy
- •3\. End\-stage chronic liver disease (Child\-Pugh C)
- •4\. End\-stage chronic kidney disease (requiring renal replacement therapy)
- •5\. Extracorporeal circulation and/or membrane oxygenation
- •6\. Ischemic stroke or intracranial bleeding within last three months
- •7\. Pregnancy and nursing
- •8\. Participation in interventional study
- •Key Exclusion Criteria Healthy Control:
Outcomes
Primary Outcomes
Not specified
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