In Vitro Models of Liver and Pancreatic Cancer

• Conditions: Hepatocellular Carcinoma; Cholangiocarcinoma; Pancreatic Neoplasm

• Registration Number: NCT02436564
• Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Brief Summary

The primary objective is to develop an in vitro model of cancer for laboratory study using liver, biliary and pancreatic cancer tissue. The secondary objective is to study the genetic and cellular biology of cancer of the liver, biliary tract and the pancreas. As well the investigators hope to compare molecular and cellular biology of cancer cells with normal cells as well as potentially test the efficacy of current and future anti-cancer therapies.

Samples will be collected from tissue that has been resected as part of the treatment for a patient diagnosed with liver, bile duct or pancreas cancer.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-04-30
• Study First Submitted QC: 2015-05-04
• Study First Posted: 2015-05-07
• Study Start: 2015-07
• Status Verified: 2016-07
• Last Update Submitted: 2016-07-13
• Last Update Posted: 2016-07-14
• Primary Completion: 2018-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• All adult patients undergoing surgical resections for liver, biliary or pancreas cancers that are able to give informed consent.

Exclusion Criteria

• Patients aged <18 or those who are unable to give informed consent.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of tumour-derived organoids successfully cultured in vitro for a minimum of 3 months.	3 years

Secondary Outcome Measures

Name	Time	Method
Proportion of tumour-derived organoids that are genetically identical to the source tumour.	3 years

Trial Locations

Locations (1)

Addenbrooke's Hospital; 🇬🇧 Cambridge, United Kingdom